The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis [PDF]
, 2016 Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase mortality.
Bosoi, Cristina R. +7 more
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Cellular and molecular mechanisms underlying muscular dystrophy [PDF]
, 2014 The muscular dystrophies are a group of heterogeneous genetic diseases characterized by progressive degeneration and weakness of skeletal muscle. Since the discovery of the first muscular dystrophy gene encoding dystrophin, a large number of genes have ...
Kunkel, Louis M., Rahimov, Fedik
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Muscle Wasting in Ageing and Chronic Illness [PDF]
ESC Heart Failure, 2015 Abstract Purpose As life expectancy increases, muscle wasting is becoming a more and more important public health problem. This review summarizes the current knowledge of pathophysiological mechanisms underlying muscle loss in ageing and chronic diseases such as heart failure and discusses ...
Ebner, Nicole +3 more
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Changes in lower limb muscle function and muscle mass following exercise-based interventions in patients with chronic obstructive pulmonary disease : a review of the English-language literature [PDF]
, 2017 Chronic obstructive pulmonary disease (COPD) patients often experience lower limb muscle dysfunction and wasting. Exercise-based training has potential to improve muscle function and mass, but literature on this topic is extensive and heterogeneous ...
Burtin, Chris +6 more
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Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model
Disease Models & Mechanisms, 2019 Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic krasG12V, we observed a progressive muscle-wasting
Qiqi Yang +3 more
doaj +1 more source
The Role of Bone in Muscle Wasting [PDF]
International Journal of Molecular Sciences, 2020 This review describes the role of bone resorption in muscle atrophy as well as in muscle protein anabolism. Both catabolic and anabolic pathways involve components of the proinflammatory cytokine families and release of factors stored in bone during resorption.
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Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice [PDF]
, 2014 BACKGROUND: Muscle wasting is frequently a result of cancers, AIDS, chronic diseases and aging, which often links to muscle inflammation. Although grape seed extract (GSE) has been widely used as a human dietary supplement for health promotion and ...
Bo Wang +4 more
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Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]
, 2020 Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S. +9 more
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protocol and rationale of a randomized clinical trial (AMINO-Stroke Study) [PDF]
, 2016 Background Patients with stroke are at a high risk for long-term handicap and disability. In the first weeks after stroke muscle wasting is observed frequently. Early post-stroke rehabilitation programs are directed to improve functional independence and
Anker, Stefan D. +9 more
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Myostatin/Smad2/Smad3 pathway define a differential clinical phenotype in COPD-associated sarcopenia
ERJ Open ResearchBackground Sarcopenia, defined as the loss of muscle mass and function, represents one of the most relevant comorbidities in patients with COPD even at early stages.
Adriana Núñez-Robainas +4 more
doaj +1 more source