Results 21 to 30 of about 945,377 (287)

Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity

Antioxidants, 2021
Skeletal muscle is the most abundant tissue in the body and is required for numerous vital functions, including breathing and locomotion. Notably, deterioration of skeletal muscle mass is also highly correlated to mortality in patients suffering from ...
Hayden W. Hyatt, Scott K. Powers
doaj   +1 more source

Sarcopenia and risk of infection in adult heart transplant recipients in Japan

ESC Heart Failure, 2022
Aims Heart transplantation (HT) is an effective therapeutic option for end‐stage heart failure. Infection is a major cause of morbidity and mortality after HT.
Masaki Tsuji, Nobutaka Kakuda, Chie Bujo, Junichi Ishida, Eisuke Amiya, Masaru Hatano, Asako Shimada, Hiroko Imai, Shogo Shimada, Osamu Kinoshita, Haruo Yamauchi, Minoru Ono, Issei Komuro   +12 more
doaj   +1 more source

Muscle-tendon cross talk during muscle wasting [PDF]

American Journal of Physiology-Cell Physiology, 2021
In organisms from flies to mammals, the initial formation of a functional tendon is completely dependent on chemical signals from muscles (myokines). However, how myokines affect the maturation, maintenance, and regeneration of tendons as a function of age is completely unstudied.
Alec M. Avey, Keith Baar
openaire   +4 more sources

Incidence of muscle wasting in the critically ill: a prospective observational cohort study

Scientific Reports, 2023
Loss of muscle mass occurs rapidly during critical illness and negatively affects quality of life. The incidence of clinically significant muscle wasting in critically ill patients is unclear.
Ondrej Hrdy, Kamil Vrbica, Marek Kovar, Tomas Korbicka, Radka Stepanova, Roman Gal   +5 more
doaj   +1 more source

Dystrophin glycoprotein complex dysfunction:a regulatory link between muscular dystrophy and cancer cachexia [PDF]

, 2005
Cachexia contributes to nearly a third of all cancer deaths, yet the mechanisms underlying skeletal muscle wasting in this syndrome remain poorly defined.
Butchbach, Matthew E R, Burghes, Arthur H M, Guttridge, Denis C, Sahenk, Zarife, Saji, Motoyasu, Acharyya, Swarnali, Ringel, Matthew D, Skipworth, Richard J E, Rafael-Fortney, Jill A, Wang, Huating, Ringel, Matthew D., Hollingsworth, Michael A, Carathers, Micheal, Fearon, Kenneth C H, Butchbach, Matthew E.R., Hollingsworth, Michael A., Muscarella, Peter, Guttridge, Denis C., Rafael-Fortney, Jill A., Skipworth, Richard J.E., Burghes, Arthur H.M., Fearon, Kenneth C.H.   +21 more
core   +1 more source

Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension

Skeletal Muscle, 2022
Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality.
Guiling Xiang, Kelu Ying, Pan Jiang, Mengping Jia, Yipeng Sun, Shanqun Li, Xiaodan Wu, Shengyu Hao   +7 more
doaj   +1 more source

Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease. [PDF]

, 2013
Skeletal muscle wasting contributes to impaired exercise capacity, health-related quality of life and is an independent determinant of chronic obstructive pulmonary disease.
Langen, R.C.J., Schols, A.M.W.J., Remels, A.H.V., Gosker, H.R.; id_orcid, Gosker, H.R.   +4 more
core   +2 more sources

Muscle Wasting in Ageing and Chronic Illness [PDF]

ESC Heart Failure, 2015
Abstract Purpose As life expectancy increases, muscle wasting is becoming a more and more important public health problem. This review summarizes the current knowledge of pathophysiological mechanisms underlying muscle loss in ageing and chronic diseases such as heart failure and discusses ...
Ebner, Nicole, Sliziuk, Veronika, Scherbakov, Nadja, Sandek, Anja   +3 more
openaire   +3 more sources

Muscle wasting as an independent predictor of survival in patients with chronic heart failure. [PDF]

, 2020
BACKGROUND Skeletal muscle wasting is an extremely common feature in patients with heart failure, affecting approximately 20% of ambulatory patients with even higher values during acute decompensation.
Garfias Macedo, Tania, Anker, Markus S, Ebner, Nicole, Anker, Stefan D, Bekfani, Tarek, Haarmann, Helge, Valentova, Miroslava, Schefold, Jörg Christian, Lainscak, Mitja, Cleland, John G F, von Haehling, Stephan, Doehner, Wolfram, Hasenfuss, Gerd   +12 more
core   +3 more sources

Myostatin/Smad2/Smad3 pathway define a differential clinical phenotype in COPD-associated sarcopenia

ERJ Open Research
Background Sarcopenia, defined as the loss of muscle mass and function, represents one of the most relevant comorbidities in patients with COPD even at early stages.
Adriana Núñez-Robainas, Maria Guitart, Adrián López-Postigo, Antonio Sancho-Muñoz, Esther Barreiro   +4 more
doaj   +1 more source