Results 71 to 80 of about 93,078 (303)

Landscape of clinical trials in cancer cachexia: assessment of trends from 1995–2024

BMC Cancer
Background Cancer cachexia, a multifactorial syndrome characterized by unintentional weight loss, is a frequent complication of cancer that impacts patients’ quality of life and survival.
Ana Regina Cabrera, Kaitlyn Parker, Deena B. Snoke, Bart Hammig, Nicholas P. Greene   +4 more
doaj   +1 more source

Cancer cachexia: Focus on cachexia factors and inter-organ communication

Chinese Medical Journal
. Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs, which is mediated by cancer cachexia factors. Cancer cachexia factors, being the general name of inflammatory factors, circulating proteins,
Yongfei Wang, Zikai Dong, Ziyi An, Weilin Jin, Sihan Zhou, Xiuyuan Hao   +5 more
doaj   +1 more source

Systemic inflammation, body composition, and physical performance in old community-dwellers [PDF]

, 2017
Background Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related ...
Addison, Addison, Bandeen-Roche, Buford, Calvani, Cesari, De Martinis, Deng, Dong, Franceschi, Goodpaster, Guralnik, Haehling, Hsu, Hughes, Hughes, Jiang, Jo, Lau, Liao, Marzetti, Marzetti, Marzetti, Opal, Peterson, Prokopchuk, Roubenoff, Seals, Szymańska, Tuttle, Varadhan, Westerhuis, Westerhuis, Zoico   +33 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Poor Outcome in a Mitochondrial Neurogastrointestinal Encephalomyopathy Patient with a Novel TYMP Mutation: The Need for Early Diagnosis. [PDF]

, 2012
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and ...
Bax, BE, Bereczki, C, Buono, R, Filosto, M, Padovani, A, Russignan, A, Scarpelli, M, Tonin, P, Zappini, F, Zombor, M   +9 more
core   +3 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

The prognostic significance of weight loss in chronic obstructive pulmonary disease‐related cachexia: a prospective cohort study

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Cachexia is an important extra‐pulmonary manifestation of chronic obstructive pulmonary disease (COPD) presenting as unintentional weight loss and altered body composition.
Hoi Yee Kwan, Matthew Maddocks, Claire M. Nolan, Sarah E. Jones, Suhani Patel, Ruth E. Barker, Samantha S.C. Kon, Michael I. Polkey, Paul Cullinan, William D.‐C. Man   +9 more
doaj   +1 more source

Cachexia index and its relationship with resection operability in patients with gastric adenocarcinoma [PDF]

Journal of Analytical Research in Clinical Medicine, 2018
Introduction: Gastric cancer is one of the relatively common malignancies all over the world, and is one of major problems of health care system. Nowadays, importance of cachexia is demonstrated in prognosis of various malignancies.
Alireza Barband, Farzad Kakaei, Reza Javadrashid, Mehrangiz Ebrahimi-Mameghani, Mohammadreza Mafi   +4 more
doaj   +1 more source

Doubled lifespan and patient‐like pathologies in progeria mice fed high‐fat diet [PDF]

, 2019
Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients ...
Albert, Carolyn J, Baldan, Angel, Bedia-Diaz, Gonzalo, Billon, Cyrielle, Burris, Thomas P, Butler, Andrew A, Ford, David A, Gonzalo, Susana, Kreienkamp, Ray, McBride-Gagyi, Sara, Toth, Zacharie   +10 more
core   +2 more sources

Cancer cachexia.

Molecular cancer, 2003
In recent years many efforts of researchers and clinicians were made to improve our knowledge of cachexia syndrome. Not only cancer, but also many chronic or end-stage diseases such as AIDS, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, tuberculosis and Crohn's disease are associated with cachexia, a condition of abnormally low ...
Kunze Philipp, Martignoni Marcus E, Friess Helmut   +2 more
openaire   +3 more sources