Results 91 to 100 of about 50,537 (264)

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Cachexia in cancer

Journal of British Surgery, 1984
H A F Dudley, R I C Wesdorp, R Krause, M F Von Meyenfeldt   +3 more
openaire   +4 more sources

Machine Learning‐Assisted Inverse Design of Soft and Multifunctional Hybrid Liquid Metal Composites

Advanced Functional Materials, EarlyView.
A machine learning framework is presented for inverse design of synthesizable multifunctional composites containing both liquid metal and solid inclusions. By integrating physics‐based modeling, data‐driven prediction, and Bayesian optimization, the approach enables intelligent design of experiments to identify optimal compositions and realize these ...
Lijun Zhou, Yunsik Ohm, Ren‐Mian Chin, Olivia Kerr, Krithika Manohar, Mohammad H. Malakooti   +5 more
wiley   +1 more source

Clinical validation of AWGC-defined cachexia in gastric cancer patients: impact on body composition and quality of life

Frontiers in Nutrition
BackgroundThe Asian Working Group for Cachexia (AWGC) has released consensus criteria for diagnosing cachexia in Asians. Nevertheless, there is limited data regarding the application of these criteria in cancer patients.
Yan Huang, Yan Huang, Xi Wu, Xi Wu, Yan Ge, Chen Wang, Xin Ding, Junbo Zuo, Junbo Zuo   +8 more
doaj   +1 more source

Tuning Separator Chemistry: Improving Zn Anode Compatibility via Functionalized Chitin Nanofibers

Advanced Functional Materials, EarlyView.
Nanochitin derived from waste shrimp shells is used to fabricate separators for aqueous zinc batteries. By tuning the density of amine and carboxylic surface groups, water mobility at the separator interface is controlled, promoting uniform zinc deposition, suppressing dendrite growth, and enabling exceptional cycling stability exceeding 2000 h ...
Ibrahim Al Kathemi, Vishnu Arumughan, Mohamed Zbiri, Marcel Kröger, Ira Smal, Eero Kontturi, Roza Bouchal   +6 more
wiley   +1 more source

Cachexia index as a biomarker for cancer cachexia and quality of life in patients with gastric cancer

BMC Cancer
Background Cachexia is associated with adverse clinical outcomes in patients with gastric cancer (GC); therefore, a convenient and reliable method for monitoring cachexia is essential.
Yan Huang, Zhenhua Huang, Wenji Hou, Chen Wang, Xiuhua Wang, Junbo Zuo   +5 more
doaj   +1 more source

Nanoengineered Binetworks in Multifunctional Anionic Block Polymer Mesoblends for Improved Mechanical Properties

Advanced Functional Materials, EarlyView.
Mesoblends consist of a nanostructured polymer into which a second polymer is imbibed with a selective solvent. In this work, a solvent‐templatable pentablock terpolymer possessing a sulfonated midblock is modified with a hydrophilic polymer that is photocrosslinked in situ, yielding a hierarchical binetwork.
Kacie M. Wells, Ivan Kuzmenko, Reza A. Ghiladi, Richard J. Spontak   +3 more
wiley   +1 more source

Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

Pharmacological Research
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients.
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps   +20 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213)

Journal of Cachexia, Sarcopenia and Muscle
Background Cancer cachexia can impact prognosis, cause resistance to anticancer treatments and affect the tolerability of treatments. This study aims to identify hepatocellular carcinoma (HCC) with cachexia by characterizing longitudinal body composition
Zhi‐Cheng Jin, Jia‐Wei Zhou, Jian‐Jian Chen, Rong Ding, Bernhard Scheiner, Si‐Na Wang, Hai‐Liang Li, Qing‐Xia Shen, Qing‐Yun Lu, Yi Liu, Wei‐Hua Zhang, Biao Luo, Hai‐Bin Shi, Ming Huang, Ye‐Ming Wu, Chun‐Wang Yuan, Ming‐Sheng Huang, Jia‐Ping Li, Jian‐Bing Wu, Xiao‐Li Zhu, Bin‐Yan Zhong, Hai‐Feng Zhou, Yu‐Qing Wang, Shan‐Zhi Gu, Zhi‐Yi Peng, Chuan‐Sheng Zheng, Rui‐Bao Liu, Guo‐Hui Xu, Wei‐Zhu Yang, Ai‐Bing Xu, Dong‐Fang Liu, Xiaolong Qi, Yee Hui Yeo, Hai‐Dong Zhu, Yang Zhao, David J. Pinato, Fanpu Ji, Gao‐Jun Teng   +37 more
doaj   +1 more source