Results 61 to 70 of about 64,866 (299)
Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series. [PDF]
BACKGROUND: In patients receiving anti-cancer treatment, cachexia results in poorer oncological outcomes. However, there is limited understanding and no systematic review of oncological endpoints in cancer cachexia (CC) trials.
Brown, LR +23 more
core +1 more source
Systemic inflammation and oxidative stress in bronchiectasis-associated sarcopenia
ERJ Open ResearchIntroduction Sarcopenia has recently been associated with bronchiectasis. We hypothesised that inflammation and oxidative stress are elevated in both systemic and muscle compartments in patients with bronchiectasis-associated sarcopenia, even in the ...
Adriana Núñez-Robainas +7 more
doaj +1 more source
The impact of pulmonary cachexia on inpatient outcomes: A national study
Annals of Thoracic Medicine, 2023 BACKGROUND: Cachexia has been associated with chronic lung disease (pulmonary cachexia syndrome), which is associated with increased mortality. However, studies that looked into this association was relatively small, and national level data are lacking ...
Mohamad Alhoda Mohamad Alahmad +1 more
doaj +1 more source
Cell, 2010 Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
, 2023 reservedCancer cachexia, a debilitating syndrome causing muscle wasting, significantly affects cancer patients' survival and quality of life. This study investigates the differential response of extraocular muscles (EOMs) and tibialis anterior (TA ...
SHARAWY, MARWAN MOHAMED NABIL MOHAMAD
core
Cancer cachexia: Focus on cachexia factors and inter-organ communication
Chinese Medical Journal. Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs, which is mediated by cancer cachexia factors. Cancer cachexia factors, being the general name of inflammatory factors, circulating proteins,
Yongfei Wang +5 more
doaj +1 more source
Aging and Cancer, EarlyView.In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara +3 more
wiley +1 more source