Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
MusclesDespite ongoing efforts, the relationship between groin strength and injury remains unclear. The challenge of accurately predicting injuries presents an opportunity for researchers to develop prevention strategies to reduce the occurrence of such ...
Afxentios Kekelekis +4 more
doaj +1 more source
Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status. Methods Our study includes both cross‐sectional and longitudinal analyses of myostatin levels in treated SMA patients.
Fiorella Piemonte +23 more
wiley +1 more source
MusclesBackground: Musculoskeletal pain is a non-negligible multifaceted condition affecting more than 30% of the global population. Superficial heat therapy (HT), through increasing tissue temperatures, plays a role in increasing local metabolism and function ...
Gustavo Zanoli +7 more
doaj +1 more source
OBSERVATIONS ON THE SENSUAL RÔLE OF THE PROPRIOCEPTIVE NERVE-SUPPLY OF THE EXTRINSIC OCULAR MUSCLES [PDF]
, 1918 Catherine Sherrington
openalex +1 more source
Combat and Warfare in the Early Paleolithic and Medically Unexplained Musculo-Facial Pain in the 21st Century War Veterns and Active-Duty Military Personnel [PDF]
, 2005 In a series of recent articles, we suggest that family dentists, military dentists and psychiatrists with expertise in posttraumatic stress disorder (especially in the Veterans Health Administration) are likely to see an increased number of patients ...
Bernstein, Dr. David M. +4 more
core
The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos +13 more
wiley +1 more source
Patellar Tendon Thermographic Reference Values in Healthy People: A Systematic Review
MusclesIntroduction: The physiological response of the tendon structure has been the subject of several studies using clinical thermography, although the lack of normal values limits clinical practice despite being, according to several authors, an optimal ...
Roberto Mevi, Alessio Cabizosu
doaj +1 more source
The Necrobiotic Nodules of Rheumatoid Arthritis: Case in Which the Scalp, Abdominal Wall (Involving Striped Muscle), Larynx, Pericardium (Involving Myocardium), Pleurae (Involving Lungs), and Peritoneum were Affected [PDF]
, 1948 Ronald W. Raven +2 more
openalex +1 more source
Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Approximately half of patients with hereditary myopathies remain without a definitive genetic diagnosis after DNA next‐generation sequencing (NGS). Here, we implemented transcriptome analysis of muscle biopsies as a complementary diagnostic tool for patients with muscle disease but no definitive genetic diagnosis after exome ...
Alba Segarra‐Casas +24 more
wiley +1 more source