Results 101 to 110 of about 37,922 (217)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE

Epilepsia Open, EarlyView.
Abstract Objective To define and articulate research priorities in epilepsy identified by the European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE), addressing key unmet needs across the spectrum of rare and complex epilepsies. Methods This position paper was developed through a structured collaborative process involving patient ...
Sébile Tchaicha, Stéphane Auvin, Sándor Beniczky, Andreas Brunklaus, Lieven Lagae, Emilio Perucca, Rainer Surges, Sophie Adler, Christoph Helmstaedter, Floor Jansen, Guido Rubboli, Philippe Ryvlin, Nicola Specchio, Eugen Trinka, Ingmar Blümcke, Valentina de Giorgis, Katarzyna Kotulska, Gaetan Lesca, Masa Malenica, Amy McTague, Rima Nabbout, Rikke Steensbjerre Møller, Sandra Silva Arrieta, Isabella Brambilla, Małgorzata Kosla, Kees Braun, J. Helen Cross, Alexis Arzimanoglou   +27 more
wiley   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Effects of physical therapy on motor ability in patients with spinal muscular atrophy III: a study protocol for a randomised controlled trial. [PDF]

BMJ Open
Zhang J, Wang B, He J, Zhu L, Dong X.
europepmc   +1 more source

Comparison of the SMI Technique and CEUS for the Assessment of Microvasculature in Leiomyosarcoma and Its Clinical Value for Application

Journal of Clinical Ultrasound, EarlyView.
SMI and CEUS can clearly reflect the microvascular situation in fibroids and effectively guide the clinical treatment of patients with uterine fibroids, but the effect of SMI is better than that of CEUS in guiding the treatment of patients, which can provide a reference for the selection of clinical treatment programs.
Qiufeng Li, Junbin Du
wiley   +1 more source

Scoliosis correction in spinal muscular atrophy : the influence of genetic severity, functional level, and disease-modifying agents on postoperative outcomes. [PDF]

Bone Jt Open
Çiftci S, Shrader MW, Hori Y, Scavina M, Heinle R, Mackenzie WG, Howard JJ.   +6 more
europepmc   +1 more source

Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Muscle wasting is a hallmark of critical illness. We evaluated the effect of amino acid supplementation and mobilization on early muscle loss in critically ill patients. Methods We conducted a randomized parallel‐group trial involving adult patients admitted to the surgical intensive care unit of a tertiary hospital.
Lizl Veldsman, Guy A. Richards, Daniel Nel, Tertius A. Kohn, Renée Blaauw   +4 more
wiley   +1 more source

A Psychometric Evaluation of Maximum Phonation Time and S/Z Ratio as Pragmatic Outcome Measures of Bulbar Function in Adults With Spinal Muscular Atrophy. [PDF]

Muscle Nerve
Slayter J, Casey L, Drost D, McCullum S, Christie A, O'Connell C.   +5 more
europepmc   +1 more source

Changes in Lower Eyelid Appearance Following Zygomaticomaxillary Complex Fractures

The Laryngoscope, EarlyView.
Several papers have recently described a loss of lower eyelid bags and resulting lower eyelid bag asymmetry in patients with orbital fractures and surgical reconstruction. This study described 104 patients with zygomaticomaxillary complex (ZMC) fractures and different treatments.
Samin Rahbin, Ola Sunnergren, Hatef Darabi, Babak Alinasab   +3 more
wiley   +1 more source