Results 141 to 150 of about 71,497 (297)

Fuel for Recovery: Predicting G‐Tube Dependence in HPV‐Negative Operable HNSCC

Head &Neck, EarlyView.
ABSTRACT Background HPV‐negative head and neck squamous cell carcinoma (HNSCC) patients can face prolonged gastrostomy tube (g‐tube) dependence, affecting quality of life and delaying treatment. Existing models lack key health metrics like sarcopenia; this study develops a risk model to enhance preoperative assessment.
Marie‐Michelle McNicoll, Alex M. Mlynarek, Keith Richardson, Michael Hier, Nader Sadeghi, Anna Casola, Nathaniel Bouganim, Khashayar Esfahani, Christina Tsien, George Shenouda, Khalil Sultanem, Marco A. Mascarella   +11 more
wiley   +1 more source

Single‐Dose Gene‐Replacement Therapy for Spinal Muscular Atrophy

New England Journal of Medicine, 2017
J. Mendell, S. Al-Zaidy, R. Shell, W. Arnold, L. Rodino-Klapac, T. Prior, L. Lowes, L. Alfano, K. Berry, K. Church, J. Kissel, S. Nagendran, J. L'italien, D. Sproule, C. Wells, J. Cardenas, M. Heitzer, A. Kaspar, Sarah E. Corcoran, L. Braun, S. Likhite, Carlos J. Miranda, K. Meyer, K. Foust, A. Burghes, B. Kaspar   +25 more
semanticscholar   +1 more source

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

Proximal spinal muscular atrophy: current orthopedic perspective

The Application of Clinical Genetics, 2013
Gerrit Haaker, Albert Fujak Department of Orthopaedic Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Abstract: Spinal muscular atrophy (SMA) is a hereditary neuromuscular disease of lower motor neurons that is ...
Haaker G, Fujak A
doaj  

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

British Journal of Clinical Pharmacology, EarlyView., 2023
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius, Dominik Pesta, Jörn Rittweger   +2 more
wiley   +1 more source

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

An examination of factors affecting the efficacy of physiotherapeutic scoliosis‐specific exercises in the management of adolescent idiopathic scoliosis

Journal of Intelligent Medicine, EarlyView.
We apologize for the omission. Please find attached the Graphical Abstract we have prepared, which visually summarizes the key elements of our study, including adolescent idiopathic scoliosis, physiotherapeutic scoliosis‐specific exercises (PSSE), influencing factors (initial Cobb angle, skeletal maturity, exercise compliance, and vertebral rotation ...
Lu Liu, Wenjie Liu, Ding Xiang, Jing Wang, Xin Li, Jiaxin Dong, Haisha Xia, Xizi Song   +7 more
wiley   +1 more source

Sonographic Anatomy and Imaging of the Extracranial Component of the Hypoglossal Nerve (CNXII)

Journal of Medical Radiation Sciences, EarlyView.
The hypoglossal nerve (HN) provides motor innervation to tongue muscles responsible for tongue movement, speech, mastication, swallowing, respiratory functions and management of oral secretions. The intracranial component of the HN can be demonstrated on magnetic resonance imaging and the extracranial component can be demonstrated with sonographic ...
Michelle Fenech, Jodie Gallagher, Laurelie R. Wishart, Clare Berry, Michael Foster‐Greenwood   +4 more
wiley   +1 more source

Congenital arthrogryposis secondary to spinal muscular atrophy: a case report

Revista de Ciencias Médicas de Pinar del Río, 2018
Introduction: spinal muscular atrophy consists of a degeneration of the anterior antlers of the spinal cord from hereditary causes with Mendelian autosomal recessive pattern leading to progressive muscle weakness of very bad prognosis.
Hernán Pereda Chávez, Ledys Mabel Fernández Hernández, Yesenia Pérez Expósito   +2 more
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