Results 141 to 150 of about 72,020 (228)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Research opportunities in muscle atrophy [PDF]

Muscle atrophy in a weightless environment is studied. Topics of investigation include physiological factors of muscle atrophy in space flight, biochemistry, countermeasures, modelling of atrophied muscle tissue, and various methods of measurement of ...
Herbison, G. J., Talbot, J. M.
core   +1 more source

The Nutritional and Bioactive Components, Potential Health Function and Comprehensive Utilization of Hawthorn: A Review

Food Frontiers, EarlyView.
This review systematically and comprehensively analyzes hawthorn (Crataegus spp.), covering its bioactive constituents, properties, and processed products. ABSTRACT Hawthorn is widely cultivated in China, with excellent varieties and steadily increasing production.
Wenteng Yang, Quanhong Gao, Kun Ran, Mingyue Jiao, Xiaodan Fu, Zhenlin Han, Chao Liu, Ningyang Li   +7 more
wiley   +1 more source

Fuel for Recovery: Predicting G‐Tube Dependence in HPV‐Negative Operable HNSCC

Head &Neck, EarlyView.
ABSTRACT Background HPV‐negative head and neck squamous cell carcinoma (HNSCC) patients can face prolonged gastrostomy tube (g‐tube) dependence, affecting quality of life and delaying treatment. Existing models lack key health metrics like sarcopenia; this study develops a risk model to enhance preoperative assessment.
Marie‐Michelle McNicoll, Alex M. Mlynarek, Keith Richardson, Michael Hier, Nader Sadeghi, Anna Casola, Nathaniel Bouganim, Khashayar Esfahani, Christina Tsien, George Shenouda, Khalil Sultanem, Marco A. Mascarella   +11 more
wiley   +1 more source

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

Magnesium Silicate Composite Patch With Neurovascular Regenerative Properties Promotes Diabetic Wound Healing in Mice

Interdisciplinary Materials, EarlyView.
The PCL‐PLLA‐MgSiO3 composite patch fabricated via electrospinning demonstrates superior therapeutic effects on diabetic wound healing compared to commercially available products, especially neurovascular network recovery. This will provide a promising bioactive patch for future clinical diabetic wound management.
Shunxiang Xu, Hongwei Shao, Zheyu Jin, Jiankun Xu, Fanyan Deng, Yuantao Zhang, Liangbin Zhou, Samuel Ka‐kin Ling, Congqin Ning, Wenxue Tong, Ling Qin   +10 more
wiley   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Sonographic Anatomy and Imaging of the Extracranial Component of the Hypoglossal Nerve (CNXII)

Journal of Medical Radiation Sciences, EarlyView.
The hypoglossal nerve (HN) provides motor innervation to tongue muscles responsible for tongue movement, speech, mastication, swallowing, respiratory functions and management of oral secretions. The intracranial component of the HN can be demonstrated on magnetic resonance imaging and the extracranial component can be demonstrated with sonographic ...
Michelle Fenech, Jodie Gallagher, Laurelie R. Wishart, Clare Berry, Michael Foster‐Greenwood   +4 more
wiley   +1 more source