Results 171 to 180 of about 72,020 (228)
The lumbar multifidus : from anatomy to rehabilitation [PDF]
, 2010 Cagnie, Barbara +2 more
core +1 more source
State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna +4 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Drug development in pediatric rare diseases is complicated by practical and ethical constraints on clinical trial design, stemming from small, highly heterogeneous, and vulnerable patient populations. Virtual patients (VPs) created with machine‐learning (ML), mechanistically driven computational approaches, or hybrids thereof, have the ...
Fianne Sips +9 more
wiley +1 more source
Sleep Research, EarlyView.Abstract Rapid eye movement (REM) sleep is a unique brain state crucial for emotion, memory, and plasticity. Unlike well‐understood non‐REM (NREM) sleep homeostasis, REM sleep homeostasis remains less clearly defined. This review highlights recent progress in understanding REM sleep homeostasis, focusing on its neurophysiological markers, neural ...
Ting He
wiley +1 more source
Small Structures, EarlyView.Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou +8 more
wiley +1 more source
Ionogel‐Dominated Wearable Sensors for Reliable Health Monitoring
SusMat, EarlyView.Ionogels have emerged as promising materials for health monitoring due to their flexibility, thermal stability, and ionic conductivity, yet challenges remain in ensuring reliable performance. This review mainly focuses on the structure‐performance relationships of ionogels towards long‐term health monitoring, including precise designs of robust ...
Wenzhe Xiao +7 more
wiley +1 more source
Review of published research on primary dysautonomia of domestic animals
Veterinary Record, EarlyView.Abstract An article published in 1992 by Marion M. Pollin and I.R. Griffiths reviewed the topic of primary dysautonomias of the autonomic nervous system of unidentified origin in multiple domestic species, specifically cats, dogs and horses. Thirty‐one years later, we appear no closer to identifying the causal agents of these strikingly similar ...
Tanith Harte +3 more
wiley +1 more source
VIEW, EarlyView.We investigated the developmental toxicity of a new graphene‐based fluorescent nanoprobe for tumor cell nucleus (GTTNs) using Oryzias melastigma embryos. The results confirmed that GTTNs have excellent biocompatibility for biomedical applications. Only the highest dose delayed hatching time.
Tianle Tang +9 more
wiley +1 more source
Centronuclear myopathy in a Labrador Retriever presenting for evaluation of a ‘bunny‐hopping’ gait
Veterinary Record Case Reports, EarlyView.Abstract A 3‐year‐old female neutered Labrador Retriever presented with a chronic history of ‘bunny‐hopping’ gait, presumed secondary to hip dysplasia. They exhibited moderate exercise intolerance, developing a stiff, short‐strided gait and collapsing into sternal recumbency after a brief period of exercise.
Aishling Lande +2 more
wiley +1 more source