Results 181 to 190 of about 393,528 (292)

Machine learning predicts treatment response to nusinersen in non-sitter spinal muscular atrophy (SMA). [PDF]

J Neuromuscul Dis
Stimpson G, O'Reilly E, Coratti G, Ridout D, Chakraborti T, Mitra R, de Sanctis R, Pane M, Scoto M, Mercuri E, Muntoni F, Baranello G, International SMA Consortium.   +12 more
europepmc   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Spinal muscular atrophy type 2 with severe kyphoscoliosis: a case report. [PDF]

J Med Case Rep
Ren W, Jin B, Hu Y, Han L, Quan R, Xiong Z.   +5 more
europepmc   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Access to care for adults living with spinal muscular atrophy in the UK. [PDF]

BMJ Neurol Open
Muni-Lofra R, Borland H, Nevin K, Rutherford A, Dungavel A, Michell-Sodhi J, Chatfield S, Pape K, Rose A, Fenty P, Martin G, Narayan S, Bartram E, Emery N, Marco MD, Manchester E, White N, Tomos H, Davies E, Morris F, Carver A, Karkkainen E, Page J, Norwood F, Davis H, Walters RJ, Dougan CF, Shanmugarajah PD, Farrugia ME, Willis TA, Brady S, Kiss-Csenki A, Merrison A, Sedehizadeh S, Brierley C, Davies NP, Galtrey CM, Parton M, Lilleker JB, Hewamadduma C, Bettolo CM.   +40 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Cognitive and neurodevelopmental outcomes in spinal muscular atrophy: a scoping review. [PDF]

Front Cell Neurosci
Gnazzo M, Pisanò G, Baldini V, Giordani S, Caiazza L, Piccolo B, Turco E, Esposito S, Pera MC.   +8 more
europepmc   +1 more source

One‐Year Changes in Frailty Components After Curative Minimally Invasive Surgery for Colorectal Cancer in Older Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Frailty predicts outcomes after colorectal cancer surgery, but postoperative changes remain unclear. We previously reported improvement in FRAIL Scale‐based frail/pre‐frail status 1 year after curative minimally invasive surgery (MIS).
Hajime Ushigome, Takuya Suzuki, Shunsuke Hayakawa, Akira Kato, Yushi Yamakawa, Kenta Saito, Hiroyuki Sagawa, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi   +9 more
wiley   +1 more source

<i>LRP12</i> CGG Repeat Expansions in Patients With Adult-Onset Non-5q Spinal Muscular Atrophy. [PDF]

Neurol Genet
Naruse H, Mitsui J, Ishiura H, Okubo S, Yoshida C, Mitsutake A, Maruta K, Uchida Y, Nobuhara Y, Okabe H, Nakamura Y, Suzuki R, Hotta Y, Matsukawa T, Tsukamoto H, Kawamura Y, Hara K, Takado Y, Kanzaki M, Uesaka Y, Ishii A, Kitamura A, Urushitani M, Takahashi Y, Kubota A, Maeda M, Shimizu J, Shirota Y, Hamada M, Satake W, Katagiri T, Takahama S, Yamamoto T, Tsuji S, Nakamura Y, Toda T.   +35 more
europepmc   +1 more source