Results 181 to 190 of about 378,998 (299)

Maternal-Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy. [PDF]

Ann Neurol
Sutton ER, Beauvais A, Yaworski R, McMillan HJ, Kothary R.   +4 more
europepmc   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Estimating the minimal clinically important difference of functional outcomes in spinal and bulbar muscular atrophy. [PDF]

J Neurol
Zanovello M, Sabbatini D, Paredi F, Romito A, Andreetta S, Blasi L, Musso G, Poletti A, Vasta R, Basso M, Dubbioso R, Pennuto M, Minicuci GM, Pegoraro E, Bello L, Sorarù G.   +15 more
europepmc   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Psychological symptoms in individuals with Spinal Muscular Atrophy (SMA) and their caregivers - results from a nation-wide study in Germany. [PDF]

Orphanet J Rare Dis
Hussong J, Leibrock B, Huelle T, Mattheus H, Landfeldt E, Thiele S, Walter MC, Zemlin M, Moehler E, Dillmann U, Flotats-Bastardas M.   +10 more
europepmc   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Utility of Far-Field Potentials as a Biomarker of Neurodegeneration in Spinal Muscular Atrophy. [PDF]

Muscle Nerve
Calma AD, Pavey N, Silva CS, Tsuji Y, Ghapar AA, Morris K, Kiernan MC, Farrar MA, Menon P, Vucic S.   +9 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Decremental responses following repetitive nerve stimulation in spinal and bulbar muscular atrophy. [PDF]

Clin Neurophysiol Pract
Tachiyama K, Nakamori M, Fujii Y, Hokkoku K, Agari D, Hemmi S, Nomura E, Hatanaka Y, Kurokawa K, Sonoo M, Maruyama H.   +10 more
europepmc   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

Advanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang, Xing Yang, Liping Liu, Yang Peng, Yangyang Wang, Hualiang Lv   +5 more
wiley   +1 more source