Results 1 to 10 of about 1,166,632 (295)

Insulin preserves fast-twitch muscle mass during early STZ-induced diabetes in rats

Biochemistry and Biophysics Reports
Purpose: Skeletal muscle atrophy is a critical complication of type 1 diabetes mellitus (T1DM), primarily caused by insulin deficiency. While physical activity is known to improve metabolic health, its effectiveness in preventing diabetes-induced muscle ...
Yuki Yamasaki, Kazuhiro Nomura, Yuka Matsumoto, Kana Fukuda-Takeji, Yumiko Miyatake, Naoya Suemasa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Masashi Kuroda, Nagakatsu Harada, Yasuo M. Tsutsumi, Tadahiro Kitamura, Rie Tsutsumi, Yutaka Nakaya, Hiroshi Sakaue   +14 more
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Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy

Advanced Science
Muscle atrophy is a chronic disease caused by multiple factors, and there is currently no effective treatment or reliable diagnostic method. Similar review articles focus on the induction and summary of the pathogenic mechanism and traditional treatment ...
Shuai Zhang, Renjie Tan, Shuo Meng, Ke Zhang, Jinlian Hu   +4 more
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Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy.

PLoS ONE, 2018
BackgroundInterleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear.MethodsTail-suspended mice were used as a disuse-induced muscle atrophy model.
Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, Yasuyoshi Ouchi, Masahiro Akishita   +6 more
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KLF13 restrains Dll4‐muscular Notch2 axis to improve the muscle atrophy

Journal of Cachexia, Sarcopenia and Muscle
Background Muscle atrophy can cause muscle dysfunction and weakness. Krüppel‐like factor 13 (KLF13), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscles and implicated in the pathogenesis of several diseases.
Shu Yang, Lijiao Xiong, Guangyan Yang, Jiaqing Xiang, Lixing Li, Lin Kang, Zhen Liang   +6 more
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Irisin regulates the phosphorylation of glucocorticoid receptor Ser212 and Ser234 and mediates glucocorticoid-induced muscle atrophy in mice

Communications Biology
Glucocorticoid-induced skeletal muscle atrophy severely limits the clinical use of glucocorticoids and occurs in various endocrine and metabolic diseases.
Jingjing Yang, Pu Zhang, Yina An, Shuyu Tan, Siqi Sun, Yifan Liu, Lin Zhu, Haidong Wang, Ting Gao, Yanjun Dong   +9 more
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Transcriptional Co‐Activator With PDZ Binding Motif (TAZ) Inhibits Dexamethasone‐Induced Muscle Atrophy via mTOR Signalling

Journal of Cachexia, Sarcopenia and Muscle
Background Glucocorticoid therapy has a beneficial effect in several diseases, but chronic treatment has adverse effects, including muscle atrophy, which refers to the gradual decrease in muscle mass, size and strength.
Kyung Min Kim, Ho Taek Oh, Youjin Do, Gi Don Yoo, Woong Heo, Jeekeon Park, Hyejin Yang, Suh Jin Yoon, Mi Ran Byun, Eun Sook Hwang, Jeong‐Ho Hong   +10 more
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N-Acetylcysteine Attenuates Sepsis-Induced Muscle Atrophy by Downregulating Endoplasmic Reticulum Stress

Biomedicines
(1) Background: Sepsis-induced muscle atrophy is characterized by a loss of muscle mass and function which leads to decreased quality of life and worsens the long-term prognosis of patients.
Renyu Chen, Yingfang Zheng, Chenchen Zhou, Hongkai Dai, Yurou Wang, Yun Chu, Jinlong Luo   +6 more
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Effect of the combination of Lithospermum erythrorhizon and Lonicera japonica on dexamethasone-induced muscle atrophy in mice

Applied Biological Chemistry
Skeletal muscle atrophy occurs in several pathological conditions. Among other reasons, high-dose or long-term administration of glucocorticoids increases circulating glucocorticoid levels and causes muscle atrophy.
Ahyoung Yoo, Hyunjung Lee, Jung-In Kim, Jeong-Hoon Hahm, Chang Hwa Jung, Jiyun Ahn   +5 more
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Leptin From Fibro‐Adipogenic Progenitor Cells (FAPs) Regulates Masseter Muscle Disuse Atrophy and Ectopic Fat Accumulation

Journal of Cachexia, Sarcopenia and Muscle
Background Excessive fat accumulation in muscles with disuse atrophy may impair muscle physiologic function and exacerbate the progression of atrophy, with causes largely unexplored.
Song Xinyi, Li Tingting, Liu Xiaoyu, Yan Hao, Li Qingchun, Liu Wei, Cheng Yuhe, Zhang Keke, Chen Yi, Gao Ang, Hong Yongfeng, Wang Yuanyin, Wu Tingting   +12 more
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Aptamer‐Conjugated Exosomes Ameliorate Diabetes‐Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a‐Mediated Mitochondrial Function

Journal of Cachexia, Sarcopenia and Muscle
Background Muscle atrophy is associated with Type 2 diabetes mellitus, which reduces the quality of life and lacks effective treatment strategies. Previously, it was determined that human umbilical cord mesenchymal stromal cell (hucMSC)–derived exosomes (
Jia Song, Mengmeng Yang, Longqing Xia, Liming Wang, Kewei Wang, Yingyue Xiang, Jun Cheng, Jun Chen, Jidong Liu, Ruxing Zhao, Fuqiang Liu, Zheng Sun, Xinguo Hou, Nan Zang, Li Chen   +14 more
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