Results 31 to 40 of about 1,927,947 (250)
Regulation of skeletal muscle atrophy
Journal of Physical Fitness and Sports Medicine, 2013 Skeletal muscle atrophy can result from prolonged periods of skeletal muscle inactivity due to bed rest, denervation, or unloading. Such unloading-associated atrophy of skeletal muscle is characterized by both an increase in protein degradation and a ...
Shigetada Teshima-Kondo, Takeshi Nikawa
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2020 Muscle atrophy is a common complication of heart failure. At present, there is no specific treatment to reverse the course of muscle atrophy. Exercise training, due to the safety and easy operation, is a recommended therapy for muscle atrophy induced by ...
Qi Liu +4 more
doaj +1 more source
Biochemical Pharmacology, 2022 Pathophysiological changes of skeletal muscle occur in a variety of chronic diseases, leading to muscle atrophy and dysfunction, which greatly affect the quality of life.
Wei Wang +11 more
semanticscholar +1 more source
A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy
Journal of Clinical Investigation, 2022 Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality is unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal muscle of limb-immobilized mice and that mice with KLF15 ...
Y. Hirata +14 more
semanticscholar +1 more source
Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear.
Ibotombi Singh Sinam +12 more
doaj +1 more source
The time course of disuse muscle atrophy of the lower limb in health and disease
Journal of Cachexia, Sarcopenia and Muscle, 2022 Short, intermittent episodes of disuse muscle atrophy (DMA) may have negative impact on age related muscle loss. There is evidence of variability in rate of DMA between muscles and over the duration of immobilization. As yet, this is poorly characterized.
E. Hardy +7 more
semanticscholar +1 more source
British Journal of Pharmacology, 2021 Increasing evidence suggests systemic inflammation‐caused skeletal muscle atrophy as a major clinical feature of cachexia. Triptolide obtained from Tripterygium wilfordii Hook F possesses potent anti‐inflammatory and immunosuppressive effects.
W. Fang +7 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of muscle atrophy.
Qiang Li +7 more
semanticscholar +1 more source
The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
Frontiers in Immunology, 2022 Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival.
Yukun Liu +6 more
semanticscholar +1 more source