Inflammation: Roles in Skeletal Muscle Atrophy
Antioxidants, 2022 Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation, mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced proteolysis.
Yanan Ji +11 more
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Potential Therapeutic Strategies for Skeletal Muscle Atrophy
Antioxidants, 2022 The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy not only seriously reduces people’s quality of life and increases morbidity and mortality, but also causes a huge socioeconomic burden.
Li Huang +11 more
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Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review
Frontiers in Nutrition, 2023 Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function, and significantly reduced load on skeletal muscle, resulting in atrophy.
Xin Xu +66 more
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The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy
Cells, 2022 Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that ...
Keisuke Hitachi +2 more
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Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy
Cells, 2020 Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, Patrice Delafontaine
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Aerobic Exercise Attenuates High-Fat Diet-Induced Skeletal Muscle Atrophy by Suppressing Oxidative Stress, Inflammation, and Drp1-Associated Mitochondrial Fission [PDF]
AntioxidantsHigh-fat diet (HFD)-induced skeletal muscle atrophy is characterized by impaired muscle mass and function, mitochondrial dysfunction, redox imbalance, and increased inflammation.
Yiwen Yuan +8 more
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Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus [PDF]
Frontiers in PhysiologyIntroductionERS-induced apoptosis may play a pivotal role in diabetic skeletal muscle atrophy. However, the specific mechanisms by which ERS regulates skeletal muscle atrophy in diabetes remain unclear.
Jingyi Yang +4 more
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Resistance Exercise Counteracts Skeletal Muscle Atrophy in T2DM Mice by Upregulating FGF21 and Activating PI3K/Akt Pathway [PDF]
BiomoleculesDecreased skeletal muscle mass and function are a serious complication of long-term diabetes, often leading to numerous adverse outcomes. The primary pathological features of diabetic sarcopenia include muscle fiber atrophy and interstitial fibrosis ...
Xiaojie Ma +5 more
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Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation [PDF]
운동과학, 2020 PURPOSE Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to ...
Dae Yun Seo +3 more
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Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Experimental Gerontology, 2023 Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
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