Epigenetic control of skeletal muscle atrophy [PDF]
Cellular & Molecular Biology LettersSkeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, and effective therapeutic
Wenpeng Liang +6 more
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HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses [PDF]
Skeletal Muscle, 2018 Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy.
Eva Pigna +7 more
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Denervation does not induce muscle atrophy through oxidative stress [PDF]
European Journal of Translational Myology, 2017 Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness.
Eva Pigna +10 more
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Potential Therapeutic Strategies for Skeletal Muscle Atrophy
Antioxidants, 2022 The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy not only seriously reduces people’s quality of life and increases morbidity and mortality, but also causes a huge socioeconomic burden.
Li Huang +11 more
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Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus [PDF]
Frontiers in PhysiologyIntroductionERS-induced apoptosis may play a pivotal role in diabetic skeletal muscle atrophy. However, the specific mechanisms by which ERS regulates skeletal muscle atrophy in diabetes remain unclear.
Jingyi Yang +4 more
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Resistance Exercise Counteracts Skeletal Muscle Atrophy in T2DM Mice by Upregulating FGF21 and Activating PI3K/Akt Pathway [PDF]
BiomoleculesDecreased skeletal muscle mass and function are a serious complication of long-term diabetes, often leading to numerous adverse outcomes. The primary pathological features of diabetic sarcopenia include muscle fiber atrophy and interstitial fibrosis ...
Xiaojie Ma +5 more
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RETRACTED: Nestin Regulates Autophagy‐Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy
Shunshun Han +8 more
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Chronic systemic inflammation by peptidoglycan‐polysaccharide induces skeletal muscle atrophy in male and ovariectomized C57BL/6J mice [PDF]
Physiological ReportsChronic systemic inflammation (CSI) induces skeletal muscle atrophy. The severity of tissue damage caused by CSI varies according to sex. However, there are still many unknowns regarding the sex differences in skeletal muscle atrophy in patients with CSI.
Ryoga Kinoshita +7 more
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Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation [PDF]
운동과학, 2020 PURPOSE Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to ...
Dae Yun Seo +3 more
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The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy
Cells, 2022 Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that ...
Keisuke Hitachi +2 more
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