Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism [PDF]
International Journal of Molecular Sciences, 2018 Antibiotics lead to increased susceptibility to colonization by pathogenic organisms, with different effects on the host-microbiota relationship. Here, we show that metronidazole treatment of specific pathogen-free (SPF) mice results in a significant increase of the bacterial phylum Proteobacteria in fecal pellets.
Ravikumar Manickam +4 more
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Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]
, 2020 Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S. +9 more
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Deubiquitinases in skeletal muscle atrophy [PDF]
The International Journal of Biochemistry & Cell Biology, 2013 The ubiquitin proteasome system plays a critical role in skeletal muscle atrophy. A large body of research has revealed that many ubiquitin ligases are induced and play an important role in mediating the wasting. However, relatively little is known about the roles of deubiquitinases in this process.
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Herbal complex 'Buyang Huanwu Tang' improves motor endplate function of denervated-dependent skeletal muscle atrophy in rat [PDF]
Journal of Integrative Neuroscience, 2020 Denervated-dependent skeletal muscle atrophy is a disease induced by skeletal muscle associated peripheral neuro-disconnection. Its specific molecular mechanisms remain unknown.
Lan Zhou, Yu-Fang Huang, Hui Xie, Xiao-Yun Mei, Jun Cao
doaj +1 more source
Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]
, 2019 Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J. +2 more
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Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates [PDF]
, 2020 Perturbations in skeletal muscle metabolism have been reported for a variety of neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve and the associated muscle atrophy is unclear.
Afzal, Shoaib +3 more
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Pharmaceuticals, 2023 Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial.
Seyedeh Elnaz Nazari +7 more
doaj +1 more source
Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis [PDF]
, 2017 Skeletal muscle myopathy is universal in cirrhotic patients, however, little is known about the main mechanisms involved. The study aims to investigate skeletal muscle morphological, histological, and functional modifications in experimental models of ...
Ascenzi, Francesca +11 more
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TWEAK and TRAF6 regulate skeletal muscle atrophy [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2012 To discuss the roles and mechanisms of action of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in skeletal muscle atrophy.Proinflammatory cytokines are known to mediate muscle atrophy in many chronic disease states.
Ashok, Kumar +2 more
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Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]
, 2015 Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya +15 more
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