Results 11 to 20 of about 122,802 (294)

Inflammation: Roles in Skeletal Muscle Atrophy

Antioxidants, 2022
Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation, mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced proteolysis.
Yanan Ji, Ming Li, Mengyuan Chang, Ruiqi Liu, Jiayi Qiu, Kexin Wang, Chunyan Deng, Yuntian Shen, Jianwei Zhu, Wei Wang, Lingchi Xu, Hualin Sun   +11 more
doaj   +5 more sources

Regulation of skeletal muscle atrophy

Journal of Physical Fitness and Sports Medicine, 2013
Skeletal muscle atrophy can result from prolonged periods of skeletal muscle inactivity due to bed rest, denervation, or unloading. Such unloading-associated atrophy of skeletal muscle is characterized by both an increase in protein degradation and a ...
Shigetada Teshima-Kondo, Takeshi Nikawa
doaj   +3 more sources

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Journal of Translational Medicine, 2023
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes.
Xin Chen, Yanan Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu, Hualin Sun   +11 more
doaj   +3 more sources

Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy

Cells, 2020
Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, Patrice Delafontaine
doaj   +3 more sources

Skeletal muscle atrophy: From mechanisms to treatments

Pharmacological Research, 2021
Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight and 50% of total protein. However, several pathological abnormalities (e.g., chronic diseases, cancer, long-term infection, aging) can induce an imbalance in skeletal muscle protein ...
Lin, Yin, Na, Li, Weihua, Jia, Nuoqi, Wang, Meidai, Liang, Xiuying, Yang, Guanhua, Du   +6 more
openaire   +4 more sources

Betulinic acid ameliorates cast‐immobilized skeletal muscle atrophy but not denervation‐induced skeletal muscle atrophy

JCSM Communications
Background Terpenoids have gained attention as therapeutic agents for skeletal muscle atrophy owing to their various physiological activities. In this study, we screened four terpenoids for their therapeutic potential against muscle atrophy in cultured ...
Yuki Enoki, Yuki Kanezaki, Isamu Takahata, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
doaj   +2 more sources

Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Experimental Gerontology, 2023
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
doaj   +1 more source

Denervation-induced activation of the standard proteasome and immunoproteasome [PDF]

, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Baumann, Cory W., Ferrington, Deborah A., Liu, Haiming M., Thompson, LaDora V.   +3 more
core   +9 more sources

Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review

Frontiers in Nutrition, 2023
Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function, and significantly reduced load on skeletal muscle, resulting in atrophy.
Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Han Ke, Han Ke, Han Ke, Han Ke, Han Ke, Han Ke, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Ying-Li Jing, Ying-Li Jing, Ying-Li Jing, Ying-Li Jing, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, De-Gang Yang, De-Gang Yang, De-Gang Yang, De-Gang Yang, De-Gang Yang   +66 more
doaj   +1 more source

Cigarette Smoking Induces Skeletal Muscle Atrophy in Mice by Activated Macrophage-Mediated Pyroptosis [PDF]

Journal of Inflammation Research
Yufen Tan,1,* Yuanyuan Ye,1,* Cuibi Huang,1 Jie Li,1 Lihua Huang,1 Xinyan Wei,1 Tong Liang,1 Enyuan Qin,1 Guolin Xiong,2 Yanfei Bin1 1Department of Respiratory and Critical Care Medicine, the second Affiliated Hospital of Guangxi Medical ...
Tan Y, Ye Y, Huang C, Li J, Huang L, Wei X, Liang T, Qin E, Xiong G, Bin Y   +9 more
doaj   +1 more source