Results 11 to 20 of about 1,143,192 (208)

Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation [PDF]

운동과학, 2020
PURPOSE Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to ...
Dae Yun Seo, Jun Hyun Bae, Hyun Seok Bang, Yi Sub Kwak   +3 more
doaj   +1 more source

The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy

Cells, 2022
Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that ...
Keisuke Hitachi, Masahiko Honda, Kunihiro Tsuchida   +2 more
doaj   +1 more source

Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Experimental Gerontology, 2023
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
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Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review

Frontiers in Nutrition, 2023
Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function, and significantly reduced load on skeletal muscle, resulting in atrophy.
Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Chun-Jia Zhang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Han Ke, Han Ke, Han Ke, Han Ke, Han Ke, Han Ke, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Yun-Zhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Hua-Yong Du, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Ying-Li Jing, Ying-Li Jing, Ying-Li Jing, Ying-Li Jing, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Liang-Jie Du, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, Jian-Jun Li, De-Gang Yang, De-Gang Yang, De-Gang Yang, De-Gang Yang, De-Gang Yang   +66 more
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HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
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Inhibiting 5‐lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin‐like growth factor‐1

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5‐
Hyun‐Jun Kim, Seon‐Wook Kim, Sang‐Hoon Lee, Da‐Woon Jung, Darren R. Williams   +4 more
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Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Nature Communications, 2023
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine.
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi   +17 more
doaj   +1 more source

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. [PDF]

PLoS ONE, 2009
Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known.
Julie Lagirand-Cantaloube, Karen Cornille, Alfredo Csibi, Sabrina Batonnet-Pichon, Marie Pierre Leibovitch, Serge A Leibovitch   +5 more
doaj   +1 more source

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]

, 2013
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph, Bentzinger, C. Florian, Guridi, Maitea, Castets, Perrine, Hall, Michael N, Tintignac, Lionel A., Hall, Michael N., Perrine Castets, Romanino, Klaas, Tintignac, Lionel, Rüegg, Markus A, Michael N Hall, Lin, Shuo, Markus A Rüegg, Bentzinger, C Florian, Christoph Handschin, Serge Summermatter, Summermatter, Serge, C Bentzinger, Klaas Romanino, Maitea Guridi, Shuo Lin, Rüegg, Markus A., Lionel A Tintignac   +23 more
core   +1 more source

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

Frontiers in Cell and Developmental Biology, 2020
Skeletal muscle atrophy is a common complication of cachexia, characterized by progressive bodyweight loss and decreased muscle strength, and it significantly increases the risks of morbidity and mortality in the population with atrophy.
Rui Chen, Si Lei, Ting Jiang, Yanling She, Huacai Shi   +4 more
doaj   +1 more source