Results 11 to 20 of about 68,097 (255)

Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation [PDF]

운동과학, 2020
PURPOSE Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to ...
Dae Yun Seo, Jun Hyun Bae, Hyun Seok Bang, Yi Sub Kwak   +3 more
doaj   +1 more source

RETRACTED: Nestin Regulates Autophagy‐Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy
Shunshun Han, Xiyu Zhao, Chunlin Yu, Can Cui, Yao Zhang, Qing Zhu, Mohan Qiu, Chaowu Yang, Huadong Yin   +8 more
doaj   +2 more sources

Chronic systemic inflammation by peptidoglycan‐polysaccharide induces skeletal muscle atrophy in male and ovariectomized C57BL/6J mice [PDF]

Physiological Reports
Chronic systemic inflammation (CSI) induces skeletal muscle atrophy. The severity of tissue damage caused by CSI varies according to sex. However, there are still many unknowns regarding the sex differences in skeletal muscle atrophy in patients with CSI.
Ryoga Kinoshita, Jay Jung, Sakura Hattori, Tatsuhiro Yamaguchi, Takaya Kotani, Karina Kouzaki, Yuki Tamura, Koichi Nakazato   +7 more
doaj   +2 more sources

The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy

Cells, 2022
Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that ...
Keisuke Hitachi, Masahiko Honda, Kunihiro Tsuchida   +2 more
doaj   +1 more source

Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Experimental Gerontology, 2023
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
doaj   +1 more source

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Inhibiting 5‐lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin‐like growth factor‐1

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5‐
Hyun‐Jun Kim, Seon‐Wook Kim, Sang‐Hoon Lee, Da‐Woon Jung, Darren R. Williams   +4 more
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Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Nature Communications, 2023
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine.
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi   +17 more
doaj   +1 more source

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. [PDF]

PLoS ONE, 2009
Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known.
Julie Lagirand-Cantaloube, Karen Cornille, Alfredo Csibi, Sabrina Batonnet-Pichon, Marie Pierre Leibovitch, Serge A Leibovitch   +5 more
doaj   +1 more source

Deubiquitinases in skeletal muscle atrophy [PDF]

The International Journal of Biochemistry & Cell Biology, 2013
The ubiquitin proteasome system plays a critical role in skeletal muscle atrophy. A large body of research has revealed that many ubiquitin ligases are induced and play an important role in mediating the wasting. However, relatively little is known about the roles of deubiquitinases in this process.
openaire   +2 more sources