Disease-Induced Skeletal Muscle Atrophy and Fatigue [PDF]
Medicine & Science in Sports & Exercise, 2016 Numerous health problems, including acute critical illness, cancer, diseases associated with chronic inflammation, and neurological disorders, often result in skeletal muscle weakness and fatigue. Disease-related muscle atrophy and fatigue is an important clinical problem because acquired skeletal muscle weakness can increase the duration of ...
Powers, Scott K. +4 more
openaire +2 more sources
Atrophy, oxidative switching and ultrastructural defects in skeletal muscle of the ataxia telangiectasia mouse model [PDF]
, 2019 Ataxia telangiectasia is a rare, multi system disease caused by ATM kinase deficiency. Atm-knockout mice recapitulate premature aging, immunodeficiency, cancer predisposition, growth retardation and motor defects, but not cerebellar neurodegeneration and
Aguanno, Salvatore +8 more
core +1 more source
The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
Frontiers in Immunology, 2022 Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival.
Yukun Liu +6 more
doaj +1 more source
Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine
Medical Sciences, 2018 Skeletal muscle comprises approximately 40% of the total body mass. Preserving muscle health and function is essential for the entire body in order to counteract chronic diseases such as type II diabetes, cardiovascular diseases, and cancer.
Manuela Cervelli +5 more
doaj +1 more source
Growth hormone plus resistance exercise attenuate structural changes in rat myotendinous junctions resulting from chronic unloading. [PDF]
, 2013 Myotendinous junctions (MTJs) are specialized sites on the muscle surface where forces generated by myofibrils are transmitted across the sarcolemma to the extracellular matrix.
Burattini, S +8 more
core +2 more sources
Mechanisms regulating skeletal muscle growth and atrophy [PDF]
The FEBS Journal, 2013 Skeletal muscle mass increases during postnatal development through a process of hypertrophy, i.e. enlargement of individual muscle fibers, and a similar process may be induced in adult skeletal muscle in response to contractile activity, such as strength exercise, and specific hormones, such as androgens and β‐adrenergic agonists.
SCHIAFFINO, STEFANO +4 more
openaire +4 more sources
Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]
, 2019 Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S. +9 more
core +1 more source
Cells, 2021 Loss of myofibers during muscle atrophy affects functional capacity and quality of life. Dexamethasone, an inducer of rapid atrophy of skeletal myofibers, has been studied as a glucocorticoid receptor in muscle atrophy or motor neurodegeneration. In this
Bomi Ryu +3 more
doaj +1 more source
Functional Classification of Skeletal Muscle Networks. I. Normal Physiology [PDF]
, 2012 Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models.
Subramaniam, Shankar +2 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source