Results 61 to 70 of about 1,143,192 (208)
Food Innovation and AdvancesSkeletal muscle atrophy resulting from glucolipid metabolic disorders poses a serious challenge to human health with the rapidly increasing prevalence of diabetes and obesity.
Mengjie Li +6 more
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Advanced Exercise and Health ScienceThe autophagy-lysosome pathway is the major route for protein and organelle clearance, and the functional status of autophagy plays an important role in the performance of skeletal muscle.
Zhengzhong Zeng +5 more
doaj +1 more source
IL-6-induced skeletal muscle atrophy [PDF]
Journal of Applied Physiology, 2005 Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase ...
Haddad, F. +3 more
openaire +4 more sources
The role of the coactivators PGC-1α and PGC-1β in retina and skeletal muscle [PDF]
, 2011 Peroxisome proliferator-activated receptor γ coactivator- 1 (PGC-1) designates a family of coactivators consisting of PGC-1α, PGC-1β and PRC. By associating with transcription factors like nuclear receptors, they induce transcription of target genes that
Egger, A, Egger, Anna Franziska
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Role of astaxanthin supplementation in prevention of disuse muscle atrophy: a review
Journal of Physical Fitness and Sports Medicine, 2019 Skeletal muscle atrophy is known to occur in various conditions, and is commonly the result of prolonged disuse of the muscle. However, no therapeutic treatment to date has been shown to completely prevent this problem.
Toshinori Yoshihara +3 more
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Skeletal muscle inflammation and atrophy in heart failure [PDF]
Heart Failure Reviews, 2017 Heart failure represents a systemic disease with profound effects on multiple peripheral tissues including skeletal muscle. Within the context of heart failure, perturbations in skeletal muscle physiology, structure, and function strongly contribute to exercise intolerance and the morbidity of this devastating disease.
Kory J, Lavine, Oscar L, Sierra
openaire +2 more sources
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy [PDF]
, 2007 The coactivator PGC-1alpha mediates key responses of skeletal muscle to motor nerve activity. We show here that neuregulin-stimulated phosphorylation of PGC-1alpha and GA-binding protein (GABP) allows recruitment of PGC-1alpha to the GABP complex and ...
Handschin, C. +11 more
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Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy. [PDF]
PLoS ONE, 2012 Important insights concerning the molecular basis of skeletal muscle disuse-atrophy and aging related muscle loss have been obtained in cell culture and animal models, but these regulatory signaling pathways have not previously been studied in aging ...
Charlotte Suetta +13 more
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A conditional mouse model for the characterization of mTORC1 function in muscle and brain [PDF]
, 2010 The Ser/Thr kinase mammalian target of rapamycin (mTOR) regulates cell growth in response to extracellular stimulation with growth factors and to intracellular factors that sense the nutritional and the energy state of the cell.
Cloëtta, Dimitri Yves Reto
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Effect of Quercetin on Dexamethasone-Induced C2C12 Skeletal Muscle Cell Injury
Molecules, 2020 Glucocorticoids are widely used anti-inflammatory drugs in clinical settings. However, they can induce skeletal muscle atrophy by reducing fiber cross-sectional area and myofibrillar protein content.
Chun Chen +7 more
doaj +1 more source