Results 81 to 90 of about 1,143,192 (208)

The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review

Chinese Journal of Traumatology, 2019
The clinical treatment of joint contracture due to immobilization remains difficult. The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis ...
Feng Wang, Quan-Bing Zhang, Yun Zhou, Shuang Chen, Peng-Peng Huang, Yi Liu, Yuan-Hong Xu   +6 more
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Muscle x-ray attenuation is not decreased during experimental bed rest. [PDF]

, 2013
Muscle X-ray attenuation (MXA) in Hounsfield units (HU) is decreased in dystrophy, aging, and immobilization. We hypothesized a decrease also during bed rest (BR).
Bareille, MARIE-PIERRE, Rittweger, Jörn, Felsenberg, Dieter, Müller, Klaus   +3 more
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The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Cellular & Molecular Biology Letters
Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle.
Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen, Xingyu Wang, Tianci Liao, Mengying Zhao, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Yan Wang, Li Zhu, Linyuan Shen   +13 more
doaj   +1 more source

Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation [PDF]

, 2010
The present investigation, the first in the field, was aimed at analyzing differentially, on individual samples, the effects of 55 days of horizontal bed rest, a model for microgravity, on myosin heavy and myosin light chain isoforms distribution (by ...
Blottner, Dieter, Michele Vasso, Bonifacio, Gaetano, Cerretelli, Paolo, C. Fania, Vasso, Michele, Salanova, Michele, Jörn Rittweger, Moriggi, Manuela, Gaetano Bonifacio, D. Capitanio, M. Salanova, M. Vasso, D. Felsenberg, G. Bonifacio, Gelfi, Cecilia, C. Gelfi, D. Blottner, Rittweger, Jörn, Paolo Cerretelli, Dieter Blottner, Chiara Fania, Capitanio, Daniele, P. Cerretelli, Cecilia Gelfi, Daniele Capitanio, Felsenberg, Dieter, Michele Salanova, Dieter Felsenberg, Fania, Chiara, M. Moriggi, J. Rittweger, Manuela Moriggi   +32 more
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Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice

Redox Biology
With increasing age, skeletal muscle gradually loses mass and strength, and the risk of falls and fractures escalates among elderly individuals. Inflammation is closely related to age-related muscle atrophy and is the potential target for treating ...
Jianjie Xie, Zongyu Huang, Nana Gao, Huicong Feng, Biaobiao Wang, Shuang Gao, He Tian, Chao Wu, Chang Liu   +8 more
doaj   +1 more source

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]

, 2009
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Richard-Bulteau, Hélène, Arnaud Ferry, Pende, Mario, Rüegg, Markus,, Hantaï, Daniel, Mario Pende, Le-Marchand-Brustel, Yannick, Kozma, Sara, Corneloup, Claudine, Laetitia Mazelin, Ferrier, Bernard, Hervé Sanchez, Koulmann, Nathalie, Claudine Corneloup, Bigard, Xavier, Daniel Hantaï, Rüegg, Markus, A., Hélène Richard-Bulteau, Mueller, Matthias, Bauché, Stéphanie, Moncollin, Vincent, Roceri, Mila, Jean-François Tanti, Conjard-Duplany, Agnès, Vignaud, Alban, Alban Vignaud, Stéphanie Bauché, Xavier Bigard, Freyssenet, Damien, Agnès Conjard-Duplany, Tanti, Jean-François, Laurent Schaeffer, Thomas, George, Mazelin, Laetitia, Defour, Aurélia, Aurélia Defour, Romanino, Klaas, Damien Freyssenet, Yannick Le-Marchand-Brustel, Bernard Ferrier, Nathalie Koulmann, George Thomas, Sanchez, Hervé, Baas, Dominique, Klaas Romanino, Sara C. Kozma, Mila Roceri, Kozma, Sara C., Rüegg, Markus A., Yann-Gaël Gangloff, Schaeffer, Laurent, Matthias Mueller, Vincent Moncollin, Markus A. Rüegg, Ferry, Arnaud, Gangloff, Yann-Gaël, Dominique Baas, Risson, Valérie, Valérie Risson   +58 more
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A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy

The Journal of Clinical Investigation, 2022
Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality is unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal muscle of limb-immobilized mice and that mice with KLF15 ...
Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa   +14 more
doaj   +1 more source

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

, 2019
Background: Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance.
Cheng, Arthur J.,, Chaillou, Thomas,, Martínez-Redondo, Vicente,, Izadi, Manizheh,, Porsmyr-Palmertz, Margareta,, Ruas, Jorge L,, Lanner, Johanna T.,, Hansson, Alicia,, Cervenka, Igor,, Agudelo, Leandro Z.,, Nair, K. Sreekumaran,, Estall, Jennifer L.,, Ferreira, Duarte M. S.,, Robinson, Matthew M.,, Valente-Silva, Paula,, Correia, Jorge C.,, Pettersson-Klein, Amanda T.,   +16 more
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Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering [PDF]

, 2016
Transplantation of human muscle precursor cells (hMPCs) is envisioned for the treatment of various muscle diseases. However, a feasible noninvasive tool to monitor cell survival, migration, and integration into the host tissue is still missing. METHODS:
Handschin, Christoph, Eberli, Daniel, Ametamey, Simon M, Dinulovic, Ivana, Salemi, Souzan, Meline Stoelting, Deana Haralampieva, Ivana Dinulovic, Tullio Sulser, Haralampieva, Deana, Krämer, Stefanie D., Sulser, Tullio, Stefanie D. Krämer, Christoph Handschin, Daniel Eberli, Thomas Betzel, Simon M. Ametamey, Stoelting, Meline, Betzel, Thomas, Souzan Salemi, Schibli, Roger, Ametamey, Simon M., Roger Schibli, Krämer, Stefanie D; https://orcid.org/   +23 more
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The role of myostatin during postnatal myogenesis and sarcopenia [PDF]

, 2007
Myostatin, a TGF-β superfamily member, is a key negative regulator of embryonic and postnatal muscle growth. In order to further elucidate the role of myostatin during postnatal growth, several lines of investigation were undertaken in mice.
Siriett, Victoria Katherine
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