Results 71 to 80 of about 1,143,192 (208)

PGC-1a in muscle links metabolism to inflammation [PDF]

, 2009
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life ...
Handschin, C.
core  

Changes in lower extremity muscle function after 56 days of bed rest [PDF]

, 2011
Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent musclefunction loss.
I. Michaelis, D. L. Belavý, Michaelis, Ingo, Belavy, Daniel, Buehring, Björn, Gast, Ulf, U. Gast, Felsenberg, Dieter, D. Felsenberg, J. Rittweger, Rittwger, Jörn, B. Buehring   +11 more
core   +1 more source

Mechanism of myostatin action during satellite cell activation and muscle wasting. [PDF]

, 2007
Myostatin, a Transforming Growth Factor-beta (TGF-β) superfamily member, has been well characterised as a negative regulator of muscle growth and development.
McFarlane, Craig Desmond
core  

A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells [PDF]

, 2012
Human primary muscle cells cultured aneurally in monolayer rarely contract spontaneously because, in the absence of a nerve component, cell differentiation is limited and motor neuron stimulation is missing(1). These limitations hamper the in vitro study
Handschin, Christoph, Arnold, Anne-Sophie, Christe, Martine   +2 more
core   +1 more source

Extracellular matrix in skeletal muscle injury and atrophy: mechanisms and therapeutic implications

Journal of Orthopaedic Translation
Extracellular matrix (ECM) is an intricate, dynamic network that is essential for structural and biochemical support of skeletal muscle cells. Upon skeletal muscle injury, ECM undergoes rapid remodeling to clear damaged tissue and provides a scaffold to ...
Xiaoyang Ge, Yesheng Jin, Jingyuan He, Zhihao Jia, Ying Liu, Yong Xu   +5 more
doaj   +1 more source

The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells [PDF]

, 2013
A persistent, low-grade inflammation accompanies many chronic diseases that are promoted by physical inactivity and improved by exercise. The beneficial effects of exercise are mediated in large part by peroxisome proliferator-activated receptor γ ...
Handschin, Christoph, Eisele, Petra S, Eisele, Petra S., Salatino, Silvia, Hottiger, Michael O., Hottiger, Michael O, Sobek, Jens   +6 more
core   +1 more source

Bulk RNA-seq of skeletal muscle reveals the role of ZBED6 in sepsis-induced muscle atrophy in minipigs

Scientific Data
Sepsis is a severe disease and induces skeletal muscle atrophy, which has a significant impact on patients. Moreover, the onset and severity of muscle atrophy can vary across different anatomical regions during sepsis.
Huan Liu, Wen Shi, Yanjun Zheng, Song Yang, Yihui Wang, Maosen Yang, Zhitao Yang, Enqiang Mao, Hanbing Shang, Erzhen Chen, Ying Chen   +10 more
doaj   +1 more source

Burn‐Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan‐Kynurenine Mediated AHR Pathway Activation

Advanced Science
The hypermetabolic response associated with burns is characterized by skeletal muscle atrophy and an increased incidence of disability and death. Significant remodeling of the gut microbiota occurs after severe burn trauma.
Shan Gao, Yan Leng, Zhen Qiu, Kai Li, Jun Li, Jian Peng, Weiguo Xie, Shaoqing Lei, Zhongyuan Xia   +8 more
doaj   +1 more source

Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]

, 1990
An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Quasthoff, Stefan, Lehmann-Horn, Frank, Strupp, Michael, Grafe, Peter, Frank Lehmann-Horn, Peter Grafe, Stefan Quasthoff, Michael Strupp   +7 more
core   +1 more source

Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.

PLoS ONE
Cancer cachexia causes skeletal muscle atrophy, impacting the treatment and prognosis of patients with advanced cancer, but no treatment has yet been established to control cancer cachexia.
Aki Sasaki, Daisuke Takeda, Hotaka Kawai, Yoshiaki Tadokoro, Aki Murakami, Nanae Yatagai, Satomi Arimoto, Hitoshi Nagatsuka, Masaya Akashi, Takumi Hasegawa   +9 more
doaj   +1 more source