Results 91 to 100 of about 1,143,192 (208)

The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition [PDF]

, 2010
Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions ...
Grocott Mike P., Edwards, Lindsay M, Holloway, CJ, Mike P Grocott, Grocott, Mike P, Edwards, LM, Neubauer, Stefan, Hugh E Montgomery, Murray Andrew J., Peter A Robbins, Robbins Peter A., Robbins, Peter A., Montgomery, Hugh E., Robbins, Peter A, Grocott, Mike P.W., Tyler Damian J., Earnest, Conrad P., Holloway Cameron J., Damian J Tyler, Murray, Andrew J, Caudwell Xtreme Everest Research Group, Clarke Kieran, Montgomery, Hugh E, Kemp Graham J., Andrew J Murray, Murray, AJ, ?, ?, Neubauer Stefan, Clarke, K, Robbins, Peter, Denny Levett, Holloway, Cameron J, Holloway, Cameron J., Kieran Clarke, Graham J Kemp, Montgomery Hugh E., Murray, Andrew J., Grocott, Mike P., Levett Denny, Grocott, MP, Caudwell Xtreme Everest Res Grp, Lindsay M Edwards, Tyler, Damian, Robbins, PA, Edwards, Lindsay M., Kemp, Graham J, Montgomery, HE, Tyler, Damian J, Levett, D, Kemp, Graham J., Neubauer, S, Tyler, DJ, Kemp, GJ, Levett, Denny, Clarke, Kieran, Cameron J Holloway, Tyler, Damian J., Stefan Neubauer, Edwards Lindsay M.   +58 more
core   +1 more source

FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension

BMC Musculoskeletal Disorders, 2007
Background Skeletal muscle atrophy can occur under many different conditions, including prolonged disuse or immobilization, cachexia, cushingoid conditions, secondary to surgery, or with advanced age. The mechanisms by which unloading of muscle is sensed
Gerrard Dave, Breur Gert, Olsen Aaron, Eash John, Hannon Kevin   +4 more
doaj   +1 more source

New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases [PDF]

, 2013
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases ...
Handschin, Christoph, Pérez-Schindler, Joaquín   +1 more
core   +1 more source

Long Non-Coding RNA Myoparr Regulates GDF5 Expression in Denervated Mouse Skeletal Muscle

Non-Coding RNA, 2019
Skeletal muscle is a highly plastic tissue and decreased skeletal muscle mass (muscle atrophy) results in deteriorated motor function and perturbed body homeostasis.
Keisuke Hitachi, Masashi Nakatani, Kunihiro Tsuchida   +2 more
doaj   +1 more source

Age-related loss of skeletal muscle function; impairment of gene expression. [PDF]

, 2004
Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I) but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation.
Goldspink, G
core  

The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling [PDF]

, 2013
Skeletal muscle mass loss and dysfunction have been linked to many diseases. Conversely, resistance exercise, mainly by activating mammalian target of rapamycin complex 1 (mTORC1), promotes skeletal muscle hypertrophy and exerts several therapeutic ...
Handschin, Christoph, Santos, Gesa, Zorzato, Francesco, Perez-Schindler, J, Zorzato, F, Summermatter, S, Summermatter, Serge, Santos, G, Pérez-Schindler, Joaquín, Handschin, C   +9 more
core   +1 more source

Effect of the combination of Lithospermum erythrorhizon and Lonicera japonica on dexamethasone-induced muscle atrophy in mice

Applied Biological Chemistry
Skeletal muscle atrophy occurs in several pathological conditions. Among other reasons, high-dose or long-term administration of glucocorticoids increases circulating glucocorticoid levels and causes muscle atrophy.
Ahyoung Yoo, Hyunjung Lee, Jung-In Kim, Jeong-Hoon Hahm, Chang Hwa Jung, Jiyun Ahn   +5 more
doaj   +1 more source

Hyperphosphatemia Contributes to Skeletal Muscle Atrophy in Mice

International Journal of Molecular Sciences
Chronic kidney disease (CKD) is associated with various pathologic changes, including elevations in serum phosphate levels (hyperphosphatemia), vascular calcification, and skeletal muscle atrophy. Elevated phosphate can damage vascular smooth muscle cells and cause vascular calcification.
Kylie Heitman, Seth Bollenbecker, Jordan Bradley, Brian Czaya, Abul Fajol, Sarah Madison Thomas, Qing Li, Svetlana Komarova, Stefanie Krick, Glenn C. Rowe, Matthew S. Alexander, Christian Faul   +11 more
openaire   +2 more sources

Atrophy and programmed cell death of skeletal muscle [PDF]

Cell Death & Differentiation, 2008
Striated skeletal is subject to nonlethal cycles of atrophy in response to a variety of physiological and pathological stimuli, including: starvation, disuse, denervation and inflammation. These cells can also undergo cell death in response to appropriate developmental signals or specific pathological insults.
openaire   +3 more sources

Betulinic acid ameliorates cast‐immobilized skeletal muscle atrophy but not denervation‐induced skeletal muscle atrophy

JCSM Communications
Background Terpenoids have gained attention as therapeutic agents for skeletal muscle atrophy owing to their various physiological activities. In this study, we screened four terpenoids for their therapeutic potential against muscle atrophy in cultured ...
Yuki Enoki, Yuki Kanezaki, Isamu Takahata, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
doaj   +1 more source