Results 21 to 30 of about 122,802 (294)

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Inhibiting 5‐lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin‐like growth factor‐1

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5‐
Hyun‐Jun Kim, Seon‐Wook Kim, Sang‐Hoon Lee, Da‐Woon Jung, Darren R. Williams   +4 more
doaj   +1 more source

Epigenetics of Skeletal Muscle Atrophy. [PDF]

Int J Mol Sci
Skeletal muscle atrophy, characterized by diminished muscle strength and mass, arises from various causes, including malnutrition, aging, nerve damage, and disease-related secondary atrophy. Aging markedly escalates the prevalence of sarcopenia. Concurrently, the incidence of muscle atrophy significantly rises among patients with chronic ailments such ...
Du J, Wu Q, Bae EJ.
europepmc   +3 more sources

Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Nature Communications, 2023
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine.
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi   +17 more
doaj   +1 more source

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. [PDF]

PLoS ONE, 2009
Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known.
Julie Lagirand-Cantaloube, Karen Cornille, Alfredo Csibi, Sabrina Batonnet-Pichon, Marie Pierre Leibovitch, Serge A Leibovitch   +5 more
doaj   +1 more source

IL-6-induced skeletal muscle atrophy [PDF]

Journal of Applied Physiology, 2005
Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase ...
Haddad, F., Zaldivar, F., Cooper, D. M, Adams, G. R   +3 more
openaire   +4 more sources

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

Frontiers in Cell and Developmental Biology, 2020
Skeletal muscle atrophy is a common complication of cachexia, characterized by progressive bodyweight loss and decreased muscle strength, and it significantly increases the risks of morbidity and mortality in the population with atrophy.
Rui Chen, Si Lei, Ting Jiang, Yanling She, Huacai Shi   +4 more
doaj   +1 more source

Redox control of skeletal muscle atrophy [PDF]

Free Radical Biology and Medicine, 2016
Skeletal muscles comprise the largest organ system in the body and play an essential role in body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important endocrine organ that contributes to the health of numerous body organs.
Scott K. Powers, Aaron B. Morton, Bumsoo Ahn, Ashley J. Smuder   +3 more
openaire   +2 more sources

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

Myoblast models of skeletal muscle hypertrophy and atrophy [PDF]

, 2011
Purpose of review: To highlight recent breakthroughs and controversies in the use of myoblast models to uncover cellular and molecular mechanisms regulating skeletal muscle hypertrophy and atrophy.
Amthor, Amthor, Anthony, Anthony, Armstrong, Castro-Gago, Chen, Dennis, DeYoung, Drummond, Findlay, Florini, Foulstone, Gentile, Glass, Heron-Milhavet, Hornberger, Jacquemin, Katagiri, Langen, Lee, Lee, Lee, Lee, Leger, Matheny, McCarthy, McFarlane, McFarlane, McPherron, McPherron, Morgan, Mudera, OʼNeil, Peng, Quinn, Rebbapragada, Rios, Saini, Sartori, Sasai, Schultz, Scime, Sharples, Spangenburg, Stewart, Stewart, Stewart, Sun, Tatsumi, Trendelenburg, Tsuchida, Wagner, Welle, Whittemore, Yamada   +55 more
core   +2 more sources