Results 11 to 20 of about 1,110,204 (301)

Development of Therapies for Spinal Muscular Atrophy Using Gene Therapy and Nanotechnology [PDF]

, 2013
Spinal muscular atrophy (SMA) is a genetic disease which is characterized by muscle weakness and atrophy. The disease arises from mutations in the survival motor neuron 1 (SMN1) gene causing degeneration of spinal cord motor neurons.
Little, Daniel
core   +6 more sources

Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis

Scientific Reports, 2021
The molecular mechanism of muscle atrophy has been studied a lot, but there is no comprehensive analysis focusing on the denervated muscle atrophy. The gene network that controls the development of denervated muscle atrophy needs further elucidation.
Xinyi Gu, Bo Jin, Zhidan Qi, Xiaofeng Yin   +3 more
doaj   +1 more source

Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b

Molecular Therapy: Nucleic Acids, 2021
The activation of the renin-angiotensin system (RAS) induced by increased angiotensin II (AngII) levels has been implicated in muscle atrophy, which is involved in the pathogenesis of congestive heart failure.
Jin Li, Tingting Yang, Zhao Sha, Haifei Tang, Xuejiao Hua, Lijun Wang, Zitong Wang, Ziyu Gao, Joost P.G. Sluijter, Glenn C. Rowe, Saumya Das, Liming Yang, Junjie Xiao   +12 more
doaj   +1 more source

Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy [PDF]

, 2021
Objective: Disuse atrophy (DA) describes inactivity-induced skeletal muscle loss, through incompletely defined mechanisms. An intriguing observation is that individual muscles exhibit differing degrees of atrophy, despite exhibiting similar anatomical ...
Inns, T.B., Hardy, E.J.O., Bass, JJ, Sale, C, Piasecki, Mathew, Smith, K., Atherton, PJ, Bass, Joseph J., Hardy, EJO, Sale, C., Wilkinson, DJ, Inns, TB, Phillips, BE, Wilkinson, D.J., Phillips, B.E., Morris, RH, Piasecki, M, Morris, R., Spicer, A, Smith, K, Spicer, A., Atherton, P.J.   +21 more
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Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Nature Communications, 2023
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine.
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi   +17 more
doaj   +1 more source

The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy

Cells, 2022
Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that ...
Keisuke Hitachi, Masahiko Honda, Kunihiro Tsuchida   +2 more
doaj   +1 more source

Interosseous muscle atrophy [PDF]

QJM, 2012
A 57-year-old woman presented with progressive upper back pain with numbness and tingling sensation over left forearm in the past 9 months. She had undergone mastectomy due to breast cancer 9 years ago and her disease relapsed 2 years ago. The physical examination revealed remarkable atrophy of interosseous muscle of left hand (Figure 1A, …
Y, Hung, M-S, Dai
openaire   +2 more sources

Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model

Pharmaceuticals, 2023
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial.
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, Majid Khazaei, Tyler W. LeBaron   +7 more
doaj   +1 more source

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]

, 2013
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph, Bentzinger, C. Florian, Guridi, Maitea, Castets, Perrine, Hall, Michael N, Tintignac, Lionel A., Hall, Michael N., Perrine Castets, Romanino, Klaas, Tintignac, Lionel, Rüegg, Markus A, Michael N Hall, Lin, Shuo, Markus A Rüegg, Bentzinger, C Florian, Christoph Handschin, Serge Summermatter, Summermatter, Serge, C Bentzinger, Klaas Romanino, Maitea Guridi, Shuo Lin, Rüegg, Markus A., Lionel A Tintignac   +23 more
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Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach [PDF]

, 2010
Oxidative stress is often associated to inactivity-mediated skeletal muscle atrophy. Glutathione is one of the major antioxidant systems stimulated, both at muscular and systemic level, by activation of oxidative processes.
DALLA LIBERA L, Francesco Agostini, Biolo, Gianni, JURDANA M, Mihaela Jurdana, Sara Mazzucco, BIOLO G., Agostini, Francesco, Jörn Rittweger, Mazzucco, Sara, Jurdana, Mihaela, Luciano Dalla Libera, Narici, Marco, Gianni Biolo, Dalla Libera, Luciano, NARICI M, MEKJAVIC IB, Rittweger, Jörn, AGOSTINI F, Igor B. Mekjavic, Pisot, Rado, PISOT R, Mekjavic, Igor, MAZZUCCO S, Gorza, Luisa, Rado Pišot, RITTWEGER J, Marco Narici, Luisa Gorza, Gorza L   +29 more
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