Results 11 to 20 of about 186,196 (308)

Protective Effect of Delta-Like 1 Homolog Against Muscular Atrophy in a Mouse Model [PDF]

Endocrinology and Metabolism, 2022
Background Muscle atrophy is caused by an imbalance between muscle growth and wasting. Delta-like 1 homolog (DLK1), a protein that modulates adipogenesis and muscle development, is a crucial regulator of myogenic programming.
Ji Young Lee, Minyoung Lee, Dong-Hee Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha   +6 more
doaj   +1 more source

Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation [PDF]

운동과학, 2020
PURPOSE Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to ...
Dae Yun Seo, Jun Hyun Bae, Hyun Seok Bang, Yi Sub Kwak   +3 more
doaj   +1 more source

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Zebrafish Model for Studying Dexamethasone-Induced Muscle Atrophy and Preventive Effect of Maca (Lepidium meyenii)

Cells, 2021
Loss of myofibers during muscle atrophy affects functional capacity and quality of life. Dexamethasone, an inducer of rapid atrophy of skeletal myofibers, has been studied as a glucocorticoid receptor in muscle atrophy or motor neurodegeneration. In this
Bomi Ryu, Jun-Geon Je, You-Jin Jeon, Hye-Won Yang   +3 more
doaj   +1 more source

Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b

Molecular Therapy: Nucleic Acids, 2021
The activation of the renin-angiotensin system (RAS) induced by increased angiotensin II (AngII) levels has been implicated in muscle atrophy, which is involved in the pathogenesis of congestive heart failure.
Jin Li, Tingting Yang, Zhao Sha, Haifei Tang, Xuejiao Hua, Lijun Wang, Zitong Wang, Ziyu Gao, Joost P.G. Sluijter, Glenn C. Rowe, Saumya Das, Liming Yang, Junjie Xiao   +12 more
doaj   +1 more source

Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis

Scientific Reports, 2021
The molecular mechanism of muscle atrophy has been studied a lot, but there is no comprehensive analysis focusing on the denervated muscle atrophy. The gene network that controls the development of denervated muscle atrophy needs further elucidation.
Xinyi Gu, Bo Jin, Zhidan Qi, Xiaofeng Yin   +3 more
doaj   +1 more source

Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis

Biochemistry and Biophysics Reports, 2023
The investigation into the effects of cold acclimation on fish skeletal muscle function and its potential implications for muscle atrophy is of great interest to us.
Daisuke Ikeda, Seina Fujita, Kaito Toda, Yuma Yaginuma, Nobuhiro Kan-no, Shugo Watabe   +5 more
doaj   +1 more source

Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Nature Communications, 2023
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine.
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi   +17 more
doaj   +1 more source

The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy

Cells, 2022
Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that ...
Keisuke Hitachi, Masahiko Honda, Kunihiro Tsuchida   +2 more
doaj   +1 more source

EIF4A3-Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1. [PDF]

J Cachexia Sarcopenia Muscle
Background Muscle atrophy is a common complication of ageing, and many chronic conditions, lacks defined therapeutic interventions. It is still mostly unknown how circular RNAs contribute to muscle atrophy.
Li J, Jin B, Yan Y, Chen Y, Yin X, Ren X, Li Q, Chen J, Wang S, Yang T, Zhang Y, Nie Q, Lu D, Wu M, Yu Y, Chen L, Keswani T, Li G, Cretoiu D, Bowen TS, Xiao J, Zheng Y.   +21 more
europepmc   +2 more sources