Results 11 to 20 of about 1,927,947 (250)
Mitochondrial dysfunction: roles in skeletal muscle atrophy
Journal of Translational Medicine, 2023 Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes.
Xin Chen +11 more
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Potential Therapeutic Strategies for Skeletal Muscle Atrophy
Antioxidants, 2022 The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy not only seriously reduces people’s quality of life and increases morbidity and mortality, but also causes a huge socioeconomic burden.
Li Huang +11 more
doaj +2 more sources
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Nature Communications, 2021 Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence general metabolism, locomotion, eating and respiration.
R. Sartori, V. Romanello, M. Sandri
semanticscholar +1 more source
Journal of Cachexia, Sarcopenia and Muscle, 2023 Diabetes and obesity are associated with muscle atrophy that reduces life quality and lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can ameliorate high fat‐diet (HFD) and immobilization (IM)‐induced muscle atrophy in mice ...
Jia Song +17 more
semanticscholar +1 more source
Mitochondrial Dysfunction and Skeletal Muscle Atrophy: Causes, Mechanisms, and Treatment Strategies.
Mitochondrion (Amsterdam. Print), 2023 Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the most dynamic and plastic tissues in the human body and plays a vital role in movement, posture and force production.
Gökhan Burçin Kubat +14 more
semanticscholar +1 more source
Ubiquitin-proteasome pathway in skeletal muscle atrophy
Frontiers in Physiology, 2023 Skeletal muscles underpin myriad human activities, maintaining an intricate balance between protein synthesis and degradation crucial to muscle mass preservation.
Xiangsheng Pang +3 more
semanticscholar +1 more source
Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions
International Journal of Molecular Sciences, 2023 Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer’s disease, and cachexia.
Lauren Jun +4 more
semanticscholar +1 more source
Scientific Reports, 2021 The molecular mechanism of muscle atrophy has been studied a lot, but there is no comprehensive analysis focusing on the denervated muscle atrophy. The gene network that controls the development of denervated muscle atrophy needs further elucidation.
Xinyi Gu +3 more
doaj +1 more source
Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b
Molecular Therapy: Nucleic Acids, 2021 The activation of the renin-angiotensin system (RAS) induced by increased angiotensin II (AngII) levels has been implicated in muscle atrophy, which is involved in the pathogenesis of congestive heart failure.
Jin Li +12 more
doaj +1 more source
GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2023 Background Obesity is related to the loss of skeletal muscle mass and function (sarcopenia). The co-existence of obesity and sarcopenia is called sarcopenic obesity (SO).
J. Xiang +4 more
semanticscholar +1 more source