Results 41 to 50 of about 1,110,204 (301)

The Relationship of Lumbar Multifidus Muscle Change to Disc Hernia and Low Back Pain: An Magnetic Resonance Imaging Study

İstanbul Medical Journal, 2019
Introduction:Our aim was to evaluate the relationship between lumbar multifidus (LM) muscle atrophy and lumbar disc herniation by magnetic resonance imaging (MRI) findings in patients with low back pain.Methods:Lumbar MRI of 264 patients aged between 18 ...
Emrah Sayıt
doaj   +1 more source

Conservative analysis of Synaptopodin‐2 intron sense‐overlapping lncRNA reveals its novel function in promoting muscle atrophy

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Dissection of the regulatory pathways that control skeletal muscle development and atrophy is important for the treatment of muscle wasting. Long noncoding RNA (lncRNA) play important roles in various stages of muscle development.
Jianjun Jin, Mengmeng Du, Jian Wang, Yubo Guo, Jiali Zhang, Hao Zuo, Yunqing Hou, Shanshan Wang, Wei Lv, Wei Bai, Jin Wang, Xizhen Zhan, Yaxin Peng, Qian Tong, Jin Chai, Zaiyan Xu, Bo Zuo   +16 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Stress responsive miR-23a attenuates skeletal muscle atrophy by targeting MAFbx /atrogin-1 [PDF]

, 2008
Muscle atrophy occurs in many pathological states and results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. We used dexamethasone to induce muscle wasting and investigated the role of a microRNA (miRNA) in the ...
Shigeru Miyaki, Yoshio Kato, Shogo Wada, Zhen Yan, Katsuhiko Suzuki, Takashi Ushida, Takayuki Akimoto, Mitsuharu Okutsu, Hiroshi Asahara   +8 more
core  

Synergistic and antagonistic effects of TNF-[alpha] and IGF-I in heart failure : "in vitro" and "in vivo" study of cardiac and skeletal muscle [PDF]

, 2006
Cardiovascular diseases are a major cause of morbidity and mortality in industrialized countries. All forms of myocardial injury first lead to compensatory hypertrophy, which eventually progresses to heart failure.
Murigande, Claire
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Involvement of microRNAs in the regulation of muscle wasting during catabolic conditions.

, 2014
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure, and in aging.
Silvestrin M, Soares R. J., Soares RJ, Chemello F., Lanfranchi G, Sandri M., Cagnin S, Musaro A., De Pitta C, De Pitta C., Silvestrin M., Lanfranchi G., Chemello F, Cagnin S., MUSARO', Antonio   +14 more
core   +1 more source

External physical and biochemical stimulation to enhance skeletal muscle bioengineering [PDF]

, 2015
Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.; In the ...
Handschin, Christoph, Eberli, Daniel, Mortezavi, Ashkan, Plock, Jan, Plock, Jan; https://orcid.org/, Eberli, Daniel; https://orcid.org/   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source