Results 51 to 60 of about 186,196 (308)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Muscle fiber atrophy

Rinsho Shinkeigaku, 2012
Muscle fibers have been classified into two major forms of red (slow twitch) and white (fast twitch) muscles. The red muscle utilizes lipid as energy source through mitochondrial metabolism and function to sustain the position against gravity (sometimes called as antigravity muscle). Under microgravity the red muscle is selectively involved.
openaire   +3 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Experimental Gerontology, 2023
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
doaj   +1 more source

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]

, 2009
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Richard-Bulteau, Hélène, Arnaud Ferry, Pende, Mario, Rüegg, Markus,, Hantaï, Daniel, Mario Pende, Le-Marchand-Brustel, Yannick, Kozma, Sara, Corneloup, Claudine, Laetitia Mazelin, Ferrier, Bernard, Hervé Sanchez, Koulmann, Nathalie, Claudine Corneloup, Bigard, Xavier, Daniel Hantaï, Rüegg, Markus, A., Hélène Richard-Bulteau, Mueller, Matthias, Bauché, Stéphanie, Moncollin, Vincent, Roceri, Mila, Jean-François Tanti, Conjard-Duplany, Agnès, Vignaud, Alban, Alban Vignaud, Stéphanie Bauché, Xavier Bigard, Freyssenet, Damien, Agnès Conjard-Duplany, Tanti, Jean-François, Laurent Schaeffer, Thomas, George, Mazelin, Laetitia, Defour, Aurélia, Aurélia Defour, Romanino, Klaas, Damien Freyssenet, Yannick Le-Marchand-Brustel, Bernard Ferrier, Nathalie Koulmann, George Thomas, Sanchez, Hervé, Baas, Dominique, Klaas Romanino, Sara C. Kozma, Mila Roceri, Kozma, Sara C., Rüegg, Markus A., Yann-Gaël Gangloff, Schaeffer, Laurent, Matthias Mueller, Vincent Moncollin, Markus A. Rüegg, Ferry, Arnaud, Gangloff, Yann-Gaël, Dominique Baas, Risson, Valérie, Valérie Risson   +58 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

ER Stress is Activated and Involved in Disuse-Induced Muscle Atrophy

Frontiers in Bioscience-Landmark, 2023
Background: Muscle atrophy resulting wholly or partially from disuse represents a serious medical complication that decreases quality of life and increases morbidity and mortality.
Lu Wang, Xiangsheng Pang, Shiming Li, Wenjiong Li, Xiaoping Chen, Peng Zhang   +5 more
doaj   +1 more source

Characterisation and expression analysis of cathepsins and ubiquitin-proteasome genes in gilthead sea bream (Sparus aurata) skeletal muscle [PDF]

, 2015
This work was supported by funds from the MICINN (AGL2009-12427 and AGL2010-17324), the Catalonian Government (2009SGR-00402) and the “Xarxa de Referència d’R + D + I en Aqüicultura” and, the European Union through the project LIFECYCLE (FP7-222719 ...
Joaquim Gutiérrez, Gutiérrez Fruitós, Joaquín, Encarnación Capilla, Navarro Álvarez, Isabel, Capilla Campos, Encarnación, Salmerón Salvador, Cristina, Johnston, Ian A., Isabel Navarro, Gutiérrez, J., Cristina Salmerón, Navarro, I., Capilla, E., Johnston, I.A., Ian A Johnston, Salmerón, C.   +14 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Optineurin binding to the novel interacting partner Junction plakoglobin prevents muscle atrophy in mice.

PLoS Biology
Skeletal muscle atrophy is a debilitating condition that significantly affects patients' quality of life and prognosis, yet its underlying mechanisms remain poorly understood.
Xiao Chen Shi, Rui Xin Zhang, Jun Kai Feng, Jia Hao Chen, Jian Feng Zhang, Jun Ying Xiao, Xiao Peng Liu, Huan Liu, Bo Xia, Li Nong Yao, Jiang Wei Wu   +10 more
doaj   +1 more source