Results 81 to 90 of about 218,393 (308)

Biglycan : a multivalent proteoglycan providing structure and signals

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Schäfer, Liliana, Năstase, Mădălina-Viviana, Young, Marian F.   +2 more
core   +1 more source

Estimated costs for Duchenne muscular dystrophy care in Brazil [PDF]

, 2023
Background: The economic burden of rare diseases on health systems is still not widely measured, with the generation of accurate information about the costs with medical care for subjects with rare diseases being crucial when defining health policies ...
Ramos, Natalia Bergamelli, Schneider, Nayê Balzan, Bevilacqua, Isabela Possebon, Polanczyk, Carisi Anne, Roos, Erica Caetano, Etges, Ana Paula Beck da Silva, Staub, Ana Lucia Portella, Almeida, Ana Carolina de, Loze, Priscilla Magalhães, Saute, Jonas Alex Morales, Martins, Tamiê de Camargo   +10 more
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Barriers to diverse clinical trial participation in Duchenne muscular dystrophy: Engaging Hispanic/Latina caregivers and health professionals

Orphanet Journal of Rare Diseases
Background Despite the increasing availability of clinical trials in Duchenne muscular dystrophy, racial/ethnic minorities and other populations facing health disparities remain underrepresented in clinical trials evaluating products for Duchenne.
Norah L. Crossnohere, Nicola B. Campoamor, Eric Camino, Erin Dresnick, Daphne Oluwaseun Martschenko, Viana Rodrigues, Susan Apkon, Alexis Hazlett, Dhruv Mittur, Priscilla E. Rodriguez, John F. P. Bridges, Niki Armstrong   +11 more
doaj   +1 more source

[Neuropathology I: muscular diseases]. [PDF]

Pathologie (Heidelb), 2023
Schänzer A, Dittmayer C, Porubsky S, Weis J, Goebel HH, Stenzel W.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Limb-girdle muscular dystrophy-associated protein diseases

, 2010
The limb-girdle muscular dystrophies are a genetically and clinically heterogeneous group of diseases. Most of these proteinopathies show wide inter- and intrafamilial phenotypic heterogeneity, so that limb-girdle involvement may be often considered as ...
Cotelli M. S., Mancuso M., Filosto M., Padovani A., Broglio L., Tentorio M., Gregorelli V., Vielmi V.   +7 more
core   +1 more source

The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases. [PDF]

Antioxidants (Basel), 2023
Zanini G, Selleri V, Malerba M, Solodka K, Sinigaglia G, Nasi M, Mattioli AV, Pinti M.   +7 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Спинально-бульбарная мышечная атрофия как мультисистемная патология с поражением мотонейронов и мышц: обзор литературы и описание клинического случая

, 2020
The spinal and bulbar muscular atrophy is a slowly progressive X-linked polysystemic disease associated with polyglutamine expansion in the androgen receptor gene. The mutant protein exhibits toxic properties towards neurons and myocytes.
С. Н. Иллариошкин, E. Yu. Fedotov, S. N. Illarioshkin, Е. О. Иванова, Е. Ю. Федотова, E. O. Ivanova   +5 more
core   +1 more source