Results 111 to 120 of about 52,464 (357)

Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals

Advanced Science, EarlyView.
A reconfigurable microneedle electrode array integrated system is developed for minimally invasive and transdermal monitoring of subcutaneous electromyography, reactive oxygen species, and pH values. By assembling discrete thumbtack‐shaped microneedles into an array, the system enables multi‐parameter detection with single‐microneedle resolution.
Zhengjie Liu, Chuanjie Yao, Xingyuan Xu, Xinshuo Huang, Shuang Huang, Shantao Zheng, Tao Zhang, Yan Li, Fanmao Liu, Yuxiang Wu, Jing Liu, Hui‐jiuan Chen, Xi Xie   +12 more
wiley   +1 more source

Role of miR-200c in myogenic differentiation impairment via p66Shc: implication in skeletal muscle regeneration of dystrophic mdx mice [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is a genetic disease associated with mutations of Dystrophin gene that regulate myofiber integrity and muscle degeneration, characterized by oxidative stress increase. We previously published that reactive oxygen species
Beji, Sara, C Capogrossi, Maurizio, D'Agostino, Marco, De Santa, Francesca, Imeneo, Giulia, Madaro, Luca, Magenta, Alessandra, Marchetti, Lorenza, Proietti, Daisy, Salis, Chiara, Sileno, Sara, Torcinaro, Alessio   +11 more
core   +3 more sources

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Mechanical Design Improvement of a Passive Device to Assist Eating in People Living with Movement Disorders [PDF]

Rehabilitation Engineering Society of North America (now Rehabilitation Engineering and Assistive Technology Society of North America (RESNA), 2020, 2020
Many people living with neurological disorders, such as cerebral palsy, stroke, muscular dystrophy or dystonia experience upper limb impairments (muscle spasticity, loss of selective motor control, muscle weakness or tremors) and have difficulty to eat independently.
arxiv  

Feasibility and tolerability of whole-body, low-intensity vibration and its effects on muscle function and bone in patients with dystrophinopathies: a pilot study. [PDF]

, 2017
IntroductionDystrophinopathies are X-linked muscle degenerative disorders that result in progressive muscle weakness complicated by bone loss. This study's goal was to evaluate feasibility and tolerability of whole-body, low-intensity vibration (WBLIV ...
Grames, Molly, Hodges, James S, Karachunski, Peter, Lowe, Dawn A, Petryk, Anna, Polgreen, Lynda E   +5 more
core   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, EarlyView.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Assessing muscle‐specific potassium concentrations in human lower leg using potassium magnetic resonance imaging

NMR in Biomedicine, Volume 36, Issue 1, January 2023., 2023
The feasibility of tissue potassium concentration (TPC) determination in individual lower leg muscles using 39K MRI at 7 T was evaluated in 14 healthy subjects. For quantification, we propose a region‐based partial volume correction approach using tissue masks extracted from high‐resolution 1H MRI data in combination with an individual signal decay for
Lena V. Gast, Laura‐Marie Baier, Oliver Chaudry, Christian R. Meixner, Max Müller, Klaus Engelke, Michael Uder, Rafael Heiss, Armin M. Nagel   +8 more
wiley   +1 more source

The Role of Alpha-Dystrobrevin in Striated Muscle [PDF]

, 2011
Muscular dystrophies are a group of diseases that primarily affect striated muscle and are characterized by the progressive loss of muscle strength and integrity.
Nakamori, Masayuki, Takahashi, Masanori P.   +1 more
core   +3 more sources

Tricky TRIC: A replication study using trophoblast retrieval and isolation from the cervix to study genetic birth defects

Prenatal Diagnosis, Volume 42, Issue 13, Page 1612-1621, December 2022., 2022
Abstract Objective Noninvasive Prenatal Diagnosis has recently been introduced for a limited number of monogenetic disorders. However, the majority of DNA diagnostics still require fetal material obtained using an invasive test. Recently, a novel technique, TRIC (Trophoblast Retrieval and Isolation from the Cervix), has been described, which collects ...
Marie van Dijk, Souad Boussata, Dianta Janssen, Gijs Afink, Jiska Jebbink, Merel van Maarle, Esther Wortelboer, Angelique Kooper, Eva Pajkrt   +8 more
wiley   +1 more source

Rule Based Expert System for Diagnosis of Neuromuscular Disorders [PDF]

arXiv, 2012
In this paper, we discuss the implementation of a rule based expert system for diagnosing neuromuscular diseases. The proposed system is implemented as a rule based expert system in JESS for the diagnosis of Cerebral Palsy, Multiple Sclerosis, Muscular Dystrophy and Parkinson's disease. In the system, the user is presented with a list of questionnaires
arxiv