Results 221 to 230 of about 29,255 (302)

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice [PDF]

Ackroyd, M R, Ashraf, A, Booler, H, Brown, S C, Fernandez-Fuente, M, Imperial College London, Kavishwar, M, Kim, J, Lacey, E, Muntoni, F, Parr, C, Terry, R, UCL, Wells, D J, Wells, K E, Whitmore, C   +15 more
core   +1 more source

Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract Oligonucleotide‐based therapeutics are now widely used in clinical settings. From the late 1980s to the mid‐1990s, efforts to improve therapeutic efficacy focused on imparting drug‐like properties to oligonucleotides, emphasizing nuclease stability and target sequence affinity.
Sudhir Agrawal
wiley   +1 more source

Ambient floor vibration sensing advances the accessibility of functional gait assessments for children with muscular dystrophies. [PDF]

Sci Rep
Dong Y, Iammarino M, Liu J, Codling J, Fagert J, Mirshekari M, Lowes L, Zhang P, Noh HY.   +8 more
europepmc   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, Volume 255, Issue 2, Page 187-208, February 2026.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

Correction to: Validation of a novel western blot assay to monitor patterns and levels of alpha dystroglycan in skeletal muscle of patients with limb girdle muscular dystrophies. [PDF]

J Muscle Res Cell Motil
Rajasingham T, Rodriguez HM, Betz A, Sproule DM, Sinha U.   +4 more
europepmc   +1 more source

Clinical Presentation of Shoulder‐Hand Syndrome: A Systematic Review

European Journal of Pain, Volume 30, Issue 2, February 2026.
ABSTRACT Background Shoulder‐hand syndrome (SHS) is a neurological disorder characterised by pain, loss of function, and trophic changes in the shoulder and hand of the affected limb. SHS shares a number of features with Complex Regional Pain Syndrome (CRPS).
Rebecca Mountford, Greta Mattocks, Heike L. Rittner, Janne Gierthmühlen, Daniel Ciampi de Andrade, Jee Youn Moon, Tara Packham, Janet H. Bultitude, Michael C. Ferraro, Peter D. Drummond, Arnas Tamasauskas, Andreas Goebel   +11 more
wiley   +1 more source

Altered Mechanical Properties of Astrocytes Lacking MLC1: Implications for the Leukodystrophy MLC

Glia, Volume 74, Issue 2, February 2026.
Mechanical properties of Mlc1‐null astrocytes are altered. Cytoskeleton‐related pathways are dysregulated in Mlc1‐null astrocytes. Mlc1‐null astrocytes show alterations in focal adhesions, which link the cytoskeleton to the extracellular matrix. ABSTRACT Loss of function of the astrocyte protein MLC1 causes Megalencephalic Leukoencephalopathy with ...
Quinty Bisseling, Emma M. J. Passchier, Freya M. Kirwan, Nelda Antonovaite, Serena Camerini, Maria S. Brignone, Amélie Freal, Huibert D. Mansvelder, Elena Ambrosini, Marjo S. van der Knaap, Rogier Min   +10 more
wiley   +1 more source

Effectiveness of conservative non-pharmacological interventions in people with muscular dystrophies: a systematic review and meta-analysis. [PDF]

J Neurol Neurosurg Psychiatry
Leone E, Pandyan A, Rogers A, Kulshrestha R, Hill J, Philp F.   +5 more
europepmc   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source