Results 151 to 160 of about 55,853 (286)

Redefining the role of the transfusion medicine physician in the era of advanced cellular therapies

Transfusion, EarlyView.
Eric A. Gehrie, Kevin J. Land
wiley   +1 more source

Decades of Misdiagnosis as Myasthenia Gravis: Late‐Onset POLG‐Related Ophthalmoplegia Unveiled by Whole‐Genome Sequencing

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT A 55‐year‐old male developed POLG‐related ophthalmoplegia in 2015 and was misdiagnosed with seronegative myasthenia gravis for 10 years. Whole‐genome sequencing identified compound heterozygous POLG mutations, highlighting its value in diagnosing refractory neuromuscular disorders.
Tanli Lu, Huadong Lv, Xiaodan Luo, Xiuying Liu   +3 more
wiley   +1 more source

Generation of a Novel Col8a2P2A‐CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation

genesis, Volume 64, Issue 2, April 2026.
ABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yong Yuan, Josiah Holt, Samuel Lorry, Yen‐Chiao Wang, Yueh‐Chiang Hu, Zhixing Ma, Adam Kaufman, Winston Kao, Diego G. Ogando, Chia‐Yang Liu   +9 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models. [PDF]

Proc Natl Acad Sci U S A
Subramanian B, Johnson S, Narayanan A, Wang W, Seaberg BL, Ball J, Paredes Mares IM, Majumder A, Aceves A, Frazier SE, Rutledge A, Griffin JF, Pal S, Zawieja S, Davis MJ, Rutkowski JM, Nghiem PP, Rimer M, Muthuchamy M.   +18 more
europepmc   +1 more source

Senescent-Like Myofibers Contribute to Anti-Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy. [PDF]

FASEB J
p16 expression in DMD model rats induces a senescent‐like state in myofibers accompanied by p16 and cytokine gene expression, reshaping systemic humoral environments. This cytokine‐rich milieu suppresses skeletal muscle regeneration, as demonstrated by impaired regeneration of transplanted wild‐type muscle.
Ikeda M, Tanaka Y, Sugihara H, Matsuwaki T, Yamanouchi K.   +4 more
europepmc   +2 more sources

Pregnancy Decision‐Making Among Women With Physical Disabilities: Cross‐Sectional Survey Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 5, Page 1016-1025, April 2026.
ABSTRACT Objective Understand the pregnancy informational needs and decision‐making of women with physical disabilities. Design Cross‐sectional. Setting Community. Sample 114 adult American women with physical disabilities who had experience making a decision about pregnancy while disabled. Methods Online survey.
Claire Z. Kalpakjian, Susan D. Ernst, Heidi J. Haapala, Melissa L. Barber, Brittany R. Orians, Lukonde Mulenga, Shannen M. McIntosh, Julia Shah, Jodi M. Kreschmer, Rebecca Parten, Sara Rosenblum, Gina M. Jay   +11 more
wiley   +1 more source

Deciphering the Presence of Active Interscapular Brown Adipose Tissue in Humans

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Brown adipose tissue (BAT) is increasingly recognized as a metabolically active tissue in humans, although its physiological relevance remains incompletely understood. In rodents, BAT is well characterized, with interscapular BAT (iBAT) representing the main thermogenic depot.
Joaquin Sanchez‐Gomez, Samuel Ruiz‐Campos, Anabel Chica‐Perez, Andrés Baena‐Raya, Francisco M. Acosta, Christian Wolfrum, Patrick C. N. Rensen, Tania Romacho, Borja Martinez‐Tellez   +8 more
wiley   +1 more source

Redefining closeness: Family resilience after sibling loss among individuals who had siblings with disabilities

Family Relations, Volume 75, Issue 2, Page 1201-1219, April 2026.
ABSTRACT Objective This qualitative study examined the experiences of individuals who had lost a sibling with a disability through a family resilience framework. Background Sibling relationships in families of individuals with disabilities are complex, with siblings often assuming caregiving roles and experiencing emotional strain.
Minhae Cho, Ji Sun Lee, Susan Neely‐Barnes, Melissa Hirschi, Keena Gilbert, J. Holden Brimhall, Tracy Humphrey   +6 more
wiley   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, Volume 59, Issue 4, Page 590-613, April 2026.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source