Results 251 to 260 of about 55,853 (286)

Altered tissue carnitine levels in animals with hereditary muscular dystrophy

Journal of the Neurological Sciences, 1978
Low levels of muscle carnitine have been found in patients with Duchenne dystrophy, a case possibly of Becker dystrophy, and limb-girdle syndrome as well as in patients with the recently described muscle carnitine deficiency syndrome. Tissues of the mouse, hamster, and chicken were analyzed to determine whether tissue carnitine levels were altered in ...
Borum, P R, Park, J H, Law, P K, Roelofs, R I   +3 more
openaire   +2 more sources

Animal models of muscular dystrophies.

Laboratory animal science, 1998
Recent advances in molecular biology have indicated that many mutant animal models of muscular dystrophy share common genetic and protein abnormalities similar to those of the human disease. The best example is a model of Duchenne muscular dystrophy (DMD), the mdx mouse.
openaire   +1 more source

Muscular Dystrophy Gene Therapy in Small Animal Models

2009
Muscular dystrophies are inherited neuromuscular disorders characterized by progressive muscle loss and weakness. The morbidity and fatality associated with the diseases and a lack of effective treatment have prompted urgent search for novel therapeutics. Gene therapy is one of the frontiers. Currently, adeno-associated viral (AAV) vector-mediated gene
Chunping Qiao, Xiao Xiao
openaire   +1 more source

Canine X-linked muscular dystrophy. An animal model of Duchenne muscular dystrophy: clinical studies.

Journal of the neurological sciences, 1989
The progression of clinical disease and serum creatine kinase (CK) levels in canine X-linked muscular dystrophy (CXMD) was studied in 7 dogs from birth to 12-14 months and in 18 dogs at varying intervals from birth to 8 weeks. One affected male was studied from age 3.5 to 6 years, and all pups were descendants of this dog.
B A, Valentine, B J, Cooper, A, de Lahunta, R, O'Quinn, J T, Blue   +4 more
openaire   +1 more source

Animal models of muscular dystrophy – what can they teach us?

Neuropathology and Applied Neurobiology, 1991
The discovery and characterization of the X‐linked gene which is defective in Duchenne muscular dystrophy (DMD) and of its protein product, dystrophin, has led to the identification of biochemical homologues of this disease in the mouse, the dog and the cat.
openaire   +2 more sources

RELEVANCE OF GENETIC ANIMAL MODELS OF MUSCULAR DYSTROPHY TO HUMAN MUSCULAR DYSTROPHIES

Annals of the New York Academy of Sciences, 1979
Mendell, J R, Higgins, R, Sahenk, Z, Cosmos, E   +3 more
openaire   +2 more sources

Muscular dystrophy of mink: a new animal model.

Federation proceedings, 1976
Muscular dystrophies comprise an important group of inherited disorders of man. Although the disease has been studied extensively, little is known about the underlying primary pathomechanisms. Consequently, treatment of patients is difficult and prognosis is poor. An animal model of muscular dystrophy is a useful research tool for approaching the basic
G A, Hegreberg, M J, Hamilton, G A, Padgett   +2 more
openaire   +1 more source

Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer

Ca-A Cancer Journal for Clinicians, 2023
exaly  

[Animal models for muscular dystrophy--muscular dystrophy in mice].

Nihon rinsho. Japanese journal of clinical medicine, 1978
S, Tsuji, H, Matsushita
openaire   +1 more source

Pharmacological strategies for muscular dystrophy

Nature Reviews Drug Discovery, 2003
Tejvir S Khurana, Kay E Davies
exaly