Results 131 to 140 of about 169,015 (342)

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice

Molecular Therapy: Nucleic Acids, 2019
Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy, with ongoing clinical trials. However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery
Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu   +4 more
doaj  

A consolidated AAV system for single-cut CRISPR correction of a common Duchenne muscular dystrophy mutation

Molecular Therapy: Methods & Clinical Development, 2021
Duchenne muscular dystrophy (DMD), caused by mutations in the X-linked dystrophin gene, is a lethal neuromuscular disease. Correction of DMD mutations in animal models has been achieved by CRISPR/Cas9 genome editing using Streptococcus pyogenes Cas9 ...
Yu Zhang, Takahiko Nishiyama, Hui Li, Jian Huang, Ayhan Atmanli, Efrain Sanchez-Ortiz, Zhaoning Wang, Alex A. Mireault, Pradeep P.A. Mammen, Rhonda Bassel-Duby, Eric N. Olson   +10 more
doaj  

α-Tocopherol Requirement of the Rat for Reproduction in the Female and Prevention of Muscular Dystrophy in the Young [PDF]

, 1941
Marianne Goettsch, A. M. Pappenheimer
openalex   +1 more source

Psychological and behavioral correlates of health anxiety and other anxiety phenomena in adolescence—A cross‐sectional study in the Copenhagen Child Cohort 2000

JCPP Advances, EarlyView.
Abstract Background Health anxiety (HA) is characterized by impairing worry about being or becoming seriously ill. This cross‐sectional study aimed to explore psychological and behavioral correlates of HA compared to other anxiety phenomena in adolescents, that is, with respect to depression, physical symptoms, bodily dissatisfaction, health‐related ...
Charlotte Steen Duholm, Davíð R. M. A. Højgaard, Kaare Bro Wellnitz, Eva Ørnbøl, Per Hove Thomsen, Martin Køster Rimvall, Charlotte Ulrikka Rask   +6 more
wiley   +1 more source

The Heart in Progressive Muscular Dystrophy [PDF]

, 1951
Jacob Zatuchni, Ernest Aegerter, Lyndall Molthan, Charles R. Shuman   +3 more
openalex   +1 more source

Illuminating Satellite Cells: Light Sheet Fluorescence Microscopy for 3D Imaging of Murine Skeletal Muscles Damaged by Ex Vivo Forced Eccentric Contraction

Microscopy Research and Technique, EarlyView.
This study presents the light sheet fluorescence microscopy (LSFM) as a tool for 3D‐imaging of whole skeletal muscle to reveal satellite cells (SCs), the muscle stem cells that activate following damage to repair injured tissue. After tissue clearing and whole‐mount staining process aimed to enable optical access and specific cell labeling (1), murine ...
Rachele Garella, Elisa Imbimbo, Francesco Palmieri, Alessia Tani, Martina Parigi, Flaminia Chellini, Alessandra La Contana, Monica Mattioli Belmonte, Aurora Longhin, Ludovico Silvestri, Chiara Sassoli, Roberta Squecco   +11 more
wiley   +1 more source

Ineffectiveness of Selenium in the Treatment of Nutritional Muscular Dystrophy in the Rabbit [PDF]

, 1957
H. H. Draper
openalex   +1 more source

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review

Journal of General and Family Medicine, EarlyView.
Abstract Objectives This narrative review identifies pitfalls in managing constipation in older adults and provides evidence‐based recommendations to avoid them. Methods A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in ...
Madunil Niriella, Hiruni Jayasena, Prathibha Wijesingha, Janaka de Silva   +3 more
wiley   +1 more source

Strategy for drug repurposing in fibroadipogenic replacement during muscle wasting: application to duchenne muscular dystrophy

Frontiers in Cell and Developmental Biology
BackgroundUnderstanding the cell functionality during disease progression or drugs’ mechanism are major challenges for precision medicine. Predictive models describing biological phenotypes can be challenging to obtain, particularly in scenarios where ...
Izzy Matthews, Izzy Matthews, Priyanka Mehra, Xavier Suárez-Calvet, Patricia Piñol-Jurado, Dan Cox, Vellia Justian, Ana Carrasco-Rozas, Zoe Laidler, Andrew Bowey, Paul Rushton, Susana López-Fernández, Jordi Díaz-Manera, Esther Fernández-Simón   +13 more
doaj   +1 more source

PATHOLOGY OF PSEUDOHYPERTROPHIC MUSCULAR DYSTROPHY [PDF]

, 1908
O. P. Johnstone
openalex   +1 more source