Results 151 to 160 of about 78,813 (265)

FDA-approved antisense oligonucleotide therapies for duchenne muscular dystrophy: current status and future outlook. [PDF]

RNA Biol
Moriyama H, Moriyama S, Yokota T.
europepmc   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

Polymorphic myopathological findings in a 77‐year‐old woman with oculo‐bulbo‐facial and distal weakness

Brain Pathology, EarlyView.
Michele Tosi, Angela Puma, Elena Faedo, Gianmarco Severa, Luisa Villa, Sabrina Sacconi, Edoardo Malfatti   +6 more
wiley   +1 more source

Diagnostic utility of inflammatory markers in formalin‐fixed and paraffin‐embedded muscle biopsies for idiopathic inflammatory myopathies

Histopathology, EarlyView.
Formalin‐fixed, paraffin‐embedded (FFPE) muscle tissue supports robust immunohistochemical detection of MHC II, MxA, and p62 with performance comparable to frozen sections. This approach reliably identifies the pathological signatures of inclusion body myositis, dermatomyositis, immune‐mediated necrotizing myopathy, and overlap myositis, enhancing the ...
Chinnawut Suriyonplengsaeng, Jariya Waisayarat   +1 more
wiley   +1 more source

Genetic, Clinical, and Management Characteristics of Duchenne Muscular Dystrophy in Saudi Arabia. [PDF]

Healthcare (Basel)
AlSaman AS, Ghamdi FA, Bamaga AK, AlShaikh N, Al Muqbil M, Muthaffar O, Bashiri FA, Ali B, Qashqari H, Heider E, Itani A, Alshahrani AA, Al Muhaizea MA.   +12 more
europepmc   +1 more source

Bone health in adults with non‐ambulatory neuromuscular disorders: scoping review of risk factors, diagnosis and management

Internal Medicine Journal, EarlyView.
Abstract Background Non‐ambulatory adults have an increased risk of osteoporosis and fractures due to reduced weight‐bearing and diminished neuromuscular stimulation, resulting in substantial morbidity and mortality. Aims This scoping review aimed to systematically evaluate risk factors, diagnostic indicators and management strategies for optimising ...
Thomas Bailey, Carolyn Droste, John A. Eisman, Steven G. Faux, Arnagretta Hunter   +4 more
wiley   +1 more source

Gene Editing Strategies for Duchenne Muscular Dystrophy: From Molecular Mechanisms to Clinical Translation. [PDF]

Cells
Siddika A, Rousseau J, Veillette F, Bouchard C, Lu Y, Tremblay JP.   +5 more
europepmc   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Loneliness in childhood is a growing public health concern, yet early multilevel candidate risk and protective factors remain insufficiently mapped. Systematic investigation is essential to guide prevention and intervention during sensitive developmental periods.
Ting Yat Wong, Ting Sam Wong, Wai Kai Hou, Angel Nga Man Leung, Jie Xiao, Kenneth S. L. Yuen, Simon S. Y. Lui, Anqi Qiu, Tyler M. Moore, Ruben C. Gur   +9 more
wiley   +1 more source

Assessing movement quality in individuals with Duchenne muscular dystrophy utilizing accelerometry: Comparisons with healthy controls. [PDF]

PLOS Digit Health
Joy N, Donnelly TJ, Soslow J, Burnette WB, Spurney C, Husain N, Gambetta K, Soriano BD, Raucci FJ, Hor K, Markham LW, Crum K, Lang CE, Miller AE, Tamaroff J, DMDCCC Investigators.   +15 more
europepmc   +1 more source