Results 171 to 180 of about 78,813 (265)

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Creatine/Creatinine Ratio and Myostatin as Biomarkers to Monitor Muscle Function in Duchenne Muscular Dystrophy Patients. [PDF]

J Cachexia Sarcopenia Muscle
Degan C, Tsonaka R, de Vries SI, Ikelaar NA, van der Holst M, Kan HE, Niks EH, Spitali P.   +7 more
europepmc   +1 more source

Deteriorating Mental Well‐Being of the Young in the UK

Scottish Journal of Political Economy, EarlyView.
ABSTRACT Using several data sets for the UK we track rising perceptions of mental well‐being among the working‐age population in the UK. The trend is apparent among all age groups and for men and women, but it is most pronounced among the young, and especially young women aged under 25.
David G. Blanchflower, Alex Bryson, David N. F. Bell   +2 more
wiley   +1 more source

Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study. [PDF]

Eur J Neurol
Sugiyama R, Takeshita E, Aihara Y, Shimizu-Motohashi Y, Izumi S, Oba M, Komaki H.   +6 more
europepmc   +1 more source

Techniques for subretinal injections in animals

Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

Generation of a novel Dysferlin microdeletion knock-in mouse model mimicking muscular dystrophy-like pathology. [PDF]

Sci Rep
Chen YL, Lin WN, Pan PY, Ku WC, Wang P, Yip PK, Tsui KC, Wu YN, Lin YH.   +8 more
europepmc   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

When pullulanase needs a little push: MyoAAV capsids enhance gene therapy for GSD IIIa

Molecular Therapy: Methods & Clinical Development
Sree Venigalla, Christina A. Pacak
doaj   +1 more source

A muscular dystrophy associated with bi-allelic LEMD2 variants: Expanding the genotype of nuclear envelopathies. [PDF]

Brain Pathol
Pauper M, Kölbel H, Karakesisoglou I, Schänzer A, Böhm J, Thompson R, Kohlschmidt N, Ringel B, Bonne G, Neuhoff K, Gangfuß A, Kilicarslan OA, Agullo SB, Hentschel A, Schara-Schmidt U, Lochmüller H, Polavarapu K, Roos A.   +17 more
europepmc   +1 more source

CARE‐ing for concussions: Development of the Calgary Adapted aRm Ergometer (CARE) exertion test: A physiological alternative to the Calgary Concussion Cycle Test

Experimental Physiology, EarlyView.
Abstract Aerobic exercise testing helps facilitate recovery post‐concussion. Current protocols (Calgary Concussion Cycling Test: CCCT) are inaccessible for athletes with lower‐body impairments (i.e. Para athletes). This study compared physiological parameters for a novel arm crank test, the Calgary Adapted aRm Ergometer (CARE) test, with the CCCT ...
Jonathan D. Smirl, Joshua J. Burkart, Matthew G. Neill, Jean‐Michel Galarneau, Elizabeth K. S. Fletcher, Joel S. Burma, Nathan E. Johnson, John J. Leddy, Mohammad N. Haider, William M. Adams, Cheri Blauwet, Chantel T. Debert, Carolyn A. Emery   +12 more
wiley   +1 more source