Results 181 to 190 of about 78,813 (265)

Elevated labile iron contributes to membrane repair deficits in facioscapulohumeral muscular dystrophy. [PDF]

iScience
Bittel AJ, Bhattacharya S, Okubamariam L, Chen YW.   +3 more
europepmc   +1 more source

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Targeting autophagy in Duchenne muscular dystrophy: mechanistic insights and emerging therapeutic strategies. [PDF]

J Med Genet
Krishna L, Srivathsa A, Anand R, Rao A, Karnik M, Vishwanath P, Dharmashekar C, Kumar Honnavalli Y, Prashant A.   +8 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Effects of Bisphosphonates on Bone Micro-Architecture of Children With Duchenne Muscular Dystrophy: A Prospective Comparative Study. [PDF]

J Cachexia Sarcopenia Muscle
Wang S, Dai Y, Meng L, Zhang Y, Sun L, Wang Y, Wang O, Jiang Y, Xia W, Xing X, Yu W, Li M.   +11 more
europepmc   +1 more source

Hemodynamic Modeling and Phase‐Adjustable Reconstruction of Hyperpolarized Cardiac 13C MRS Using 1H Cine and ECG Timing

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1054-1065, September 2026.
ABSTRACT Purpose To deconvolve cardiac phase and hemodynamic effects in hyperpolarized (HP) [1‐13C]pyruvate and to develop a cardiac phase‐adjustable reconstruction framework. Methods Cardiac phase drift during dynamic acquisition of HP 13C MRS and its effect on dynamic signal fidelity were simulated using a digital cardiac phantom. A hemodynamic model
Sung‐Han Lin, Corey Mozingo, Crystal E. Harrison, Kelley A. Derner, Craig R. Malloy, Jae Mo Park   +5 more
wiley   +1 more source

Phospho-mimic βIII-tubulin rescues microtubule and cardiac defects in Duchenne muscular dystrophy mice. [PDF]

J Mol Cell Cardiol
Zhou D, Nouet J, Mesa E, Yegneshwaran V, Geukgeuzian G, Adibemma ID, Ramirez E, Ali NK, Hilfiker S, Li H, Liu T, Yehia G, Romanienko PJ, Rodney GG, Wehrens XHT, Lampe PD, Gourdie RG, Xie LH, Fraidenraich D.   +18 more
europepmc   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, Volume 270, Issue 1, Page 83-97, September 2026.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source