Results 81 to 90 of about 9,725,589 (384)

How to score the wrist joint by ultrasound: exploration of the most sensitive joint assessment during follow-up of early or established rheumatoid arthritis

Arthritis Research & Therapy
Background Wrist inflammation is common in patients with rheumatoid arthritis (RA), and thus there is room for debate on which joints to include in an ultrasound-based scoring of wrist synovitis in RA.
Yusuke Yoshida, Hilde Berner Hammer, Joseph Sexton, Lena Nordberg, Anna-Birgitte Aga, Lene Terslev, Siri Lillegraven, Espen A. Haarvardsholm   +7 more
doaj   +1 more source

Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis

Osteoarthritis and Cartilage Open
Objective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive ...
Alexander Mathiessen, Line Gaundal, Joseph Sexton, Dag Sjølie, Pernille Steen Pettersen, Barbara Slatkowsky-Christensen, Ida Kristin Haugen   +6 more
doaj   +1 more source

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression

Scientific Reports, 2017
C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son, Betty Diamond, Bruce T. Volpe, Cynthia B. Aranow, Meggan C. Mackay, Frances Santiago-Schwarz   +5 more
doaj   +1 more source

Older age, comorbidity, glucocorticoid use and disease activity are risk factors for COVID-19 hospitalisation in patients with inflammatory rheumatic and musculoskeletal diseases

RMD Open, 2021
Introduction Whether patients with inflammatory rheumatic and musculoskeletal diseases (RMD) are at higher risk to develop severe courses of COVID-19 has not been fully elucidated. Aim of this analysis was to describe patients with RMD according to their
R. Hasseli, U. Mueller-Ladner, B. Hoyer, A. Krause, H. Lorenz, A. Pfeil, J. Richter, M. Schäfer, T. Schmeiser, A. Strangfeld, H. Schulze-Koops, R. Voll, C. Specker, A. Regierer   +13 more
semanticscholar   +1 more source

Proportion of Acceptable Symptom State Nearly Tripled With Improvements in Patient‐Reported Outcomes for All Symptom State Subgroups: A Registry Study of More Than 15,000 Patients With Osteoarthritis in Digital Education and Exercise Therapy

Arthritis Care &Research, EarlyView.
Objective This study investigated trajectories of patient acceptable symptom state (PASS) among participants of digital education and exercise therapy for knee and hip osteoarthritis. Methods A longitudinal observational study among individuals aged at least 40 years who participated in the digital program.
Ali Kiadaliri, L. Stefan Lohmander, Amanda E. Nelson, Leif E. Dahlberg   +3 more
wiley   +1 more source

Risk and prognosis of SARS-CoV-2 infection and vaccination against SARS-CoV-2 in rheumatic and musculoskeletal diseases: a systematic literature review to inform EULAR recommendations

Annals of the Rheumatic Diseases, 2021
Objectives Perform a systematic literature review (SLR) on risk and prognosis of SARS-CoV-2 infection and vaccination against SARS-CoV-2 in patients with rheumatic and musculoskeletal diseases (RMDs).
F. Kroon, A. Najm, A. Alunno, J. Schoones, R. Landewé, P. Machado, V. Navarro-Compán   +6 more
semanticscholar   +1 more source

IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation

Scientific Reports
Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the immune system and enable pre-metastatic niche (PMN) formation.
Bailey K. Roberts, Dan Iris Li, Carter Somerville, Bharati Matta, Vaishali Jha, Adison Steinke, Zarina Brune, Lionel Blanc, Samuel Z. Soffer, Betsy J. Barnes   +9 more
doaj   +1 more source

SARS-CoV-2 vaccine hesitancy among patients with rheumatic and musculoskeletal diseases: a message for rheumatologists

Annals of the Rheumatic Diseases, 2021
Conflicting results have been published regarding the risk of infection with SARS-CoV-2 and development of severe COVID-19 among patients affected by rheumatic musculoskeletal diseases (RMDs).
R. Priori, G. Pellegrino, S. Colafrancesco, C. Alessandri, F. Ceccarelli, M. Di Franco, V. Riccieri, R. Scrivo, A. Sili Scavalli, F. Spinelli, F. Conti   +10 more
semanticscholar   +1 more source

Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond Y. H. Yap, Ka Lai Lee, Philip H. Li, Iris Y. K. Tang, Chak Sing Lau, Shirley C. W. Chan   +6 more
wiley   +1 more source

Altered mechanotransduction in adolescent idiopathic scoliosis osteoblasts: an exploratory in vitro study

Scientific Reports, 2022
Adolescent idiopathic scoliosis (AIS) is the most prevalent pediatric spinal deformity. We previously demonstrated elongated cilia and an altered molecular mechanosensory response in AIS osteoblasts.
Niaz Oliazadeh, Kristen F. Gorman, Mohamed Elbakry, Alain Moreau   +3 more
doaj   +1 more source