Results 81 to 90 of about 386,189 (210)

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

eLife, 2016
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain.
Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea   +11 more
doaj   +1 more source

The Role of Nuclear and Mitochondrial DNA in Myalgic Encephalomyelitis: Molecular Insights into Susceptibility and Dysfunction

DNA
Myalgic Encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), is a debilitating and heterogeneous disorder marked by persistent fatigue, post-exertional malaise, cognitive impairment, and multisystem dysfunction.
Wesam Elremaly, Mohamed Elbakry, Yasaman Vahdani, Anita Franco, Alain Moreau   +4 more
doaj   +1 more source

Biphasic control of the B cell transcriptome by mTORC1 and GSK3

Cell Reports
Summary: A central question in immune regulation is how cells coordinate transcriptional responses to environmental cues. It remains unclear whether transcriptional regulation is controlled by isolated mechanism or integrated regulatory programs.
Jens Kalchschmidt, Tomoya Kanno, Solji Park, Wendy D. Dubois, Yongbing Zhao, Pawel Trzaskoma, Craig J. Thomas, Louis M. Staudt, John J. O’Shea, Seolkyoung Jung, Rafael Casellas   +10 more
doaj   +1 more source

Incidence of and survival after surgery for metastatic spine disease: a nationwide register-based study between 1997 and 2020 from Finland

Acta Orthopaedica
Background and purpose: Information on metastatic spine disease (MSD) based on nationwide data on trends and postoperative survival is limited but is needed to optimize treatment in this population. We aimed to assess the incidence of and survival rates
Leevi A Toivonen, Ville Ponkilainen, Jussi P Repo, Ville M Mattila   +3 more
doaj   +1 more source

The Frequency of Musculoskeletal Disorders in Students of Tehran, Tehran, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
<p><strong><em>Background and Objectives:</em></strong> Musculoskeletal disorders are common among children. Burden imposed on neck, shoulder and back areas by carrying schoolbags may result in musculoskeletal disorders in ...
AR Shamsoddini
doaj   +2 more sources

Podiatry services for patients with arthritis: an unmet need [PDF]

, 2010
Foot problems are extremely common in patients with rheumatoid arthritis (RA). There is ample evidence that foot pain, either alone or as a comorbidity, contributes significantly to disability.
Chapman, J, Dalbeth, N, Gow, P, Rome, K, Williams, AE   +4 more
core   +1 more source

Design of Force Meter for Traction Unit [PDF]

, 2019
Force gauge is an instrument used to measure the force on the traction unit. The purpose of this study is made a force gauge meter which used during traction operation. The main component of this force gauge meter is Atmega 328, HX711 module and Loadcell
Aprilyana, G. (Gita), Setioningsih, E. D. (Endang), Triwiyanto, T. (Triwiyanto)   +2 more
core  

Allocation of rehabilitation measures provided by the Social Insurance Institution in Finland: A register linkage study [PDF]

, 2007
Hinkka, K, Kivimaki, M, Klaukka, T, Pentti, J, Suoyrjo, H, Vahtera, J   +5 more
core   +1 more source

Occupational Injuries and Illnesses: A Pilot Study of Job-Transfer or Work-Restriction Cases, 2012 [PDF]

, 2014
[Excerpt] The Bureau of Labor Statistics (BLS) conducted a pilot study to learn more about the case circumstances and worker characteristics for occupational injury and illness cases that resulted in days of job transfer or work restriction for workers ...
Bureau of Labor Statistics
core   +2 more sources

Therapeutic serum level for adalimumab in rheumatoid arthritis: explorative analyses of data from a randomised phase III trial

RMD Open
Objectives The objectives of this study are to identify a therapeutic serum level for adalimumab associated with remission and low disease activity in patients with rheumatoid arthritis.Methods Associations between serum adalimumab trough levels and ...
Joseph Sexton, Daniel Aletaha, Eirik Klami Kristianslund, Espen Andre Haavardsholm, Nils Bolstad, Johanna Elin Gehin, Silje Watterdal Syversen, David John Warren, Guro Løvik Goll, Ingrid Jyssum, Rolf Anton Klaasen   +10 more
doaj   +1 more source