Results 211 to 220 of about 1,292,876 (289)

Treatment‐driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B‐cell therapy in Sjögren's disease

open access: yesArthritis &Rheumatology, Accepted Article.
Objective To characterise whole‐blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non‐response. Methods Whole‐blood RNA sequencing was performed at baseline and week‐24 in participants (n=43) from a
Aimen Ibrahim   +9 more
wiley   +1 more source

Musculoskeletal Pain During Late Adolescence: The Generation R Study. [PDF]

open access: yesEur J Pain
van Paassen R   +3 more
europepmc   +1 more source

A survey on the teaching of introductory nervous system content in undergraduate courses

open access: yesAnatomical Sciences Education, EarlyView.
Abstract Teaching introductory or foundation level concepts about anatomy and physiology of the nervous system to undergraduate students presents a conundrum for educators—how to provide students with sufficient knowledge for a successful learning experience and outcome without overwhelming students and impacting student progression and retention.
Gabrielle Todd   +2 more
wiley   +1 more source

Arthroscopic Anterior Talofibular Ligament Repair Without Anchors for Chronic Lateral Ankle Instability

open access: yesArthroscopy Techniques, EarlyView.
Abstract In recent years, arthroscopic anterior talofibular ligament (ATFL) repair techniques have been increasingly used in the treatment of chronic ankle instability. Arthroscopic approaches not only allow for the management of concomitant intra‐articular pathologies but also help minimize wound‐related complications associated with open surgery and ...
Semih Yaş   +5 more
wiley   +1 more source

Climatic determinants of rheumatic and autoimmune musculoskeletal pain: a fourteen-year primary care time-series study. [PDF]

open access: yesSci Rep
Cuenca-Zaldívar JN   +9 more
europepmc   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad   +4 more
wiley   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé   +12 more
wiley   +1 more source

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