Results 171 to 180 of about 1,865,735 (228)
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Identification of adducts formed between phosphatidylcholine and mustard agents. [PDF]
Kjellberg MA +4 more
europepmc +1 more source
Abstract Ecological niche models (ENMs) are used to assess the abiotic preferences of species by linking their occurrences to the environmental conditions in which they live. We developed a fossil‐informed ENM framework that integrates mid‐Holocene and modern occurrences to test niche stability and reconstruct abiotic niche characteristics for four ...
Claire. M. Williams +3 more
wiley +1 more source
Exogenous copper oxide nanoparticle treatment (seed and foliar) modifies photosynthetic rate and antioxidant enzyme activity in <i>Brassica juncea</i>. [PDF]
Faraz A +5 more
europepmc +1 more source
ABSTRACT This work focuses on the polymeric steric entrapment (PSE) technique to synthesize a series of (nRE1/n)3Al5O12, or compositionally complex rare‐earth aluminum garnet (CCREAG) compositions, where RE represents a variety of rare‐earth cations and n is the number of cations occupying the shared position. Using PSE, CCREAGs crystallized at ∼900°C.
Vincent Joseph Garcia +9 more
wiley +1 more source
Linking fatty acid composition to enzyme inhibition supported by molecular docking, alongside multifunctional bioactivities, of avocado, Indian mustard, and passion fruit seed oils. [PDF]
Fratianni F +10 more
europepmc +1 more source
Pulmonary venous baffle stenosis following atrial switch repair for transposition of the great arteries. [PDF]
Padala SRAN +3 more
europepmc +1 more source
Abstract Hardware released during spacecraft entry can generate hypervelocity impacts that provide unique constraints on planetary subsurface properties. During NASA's Perseverance descent, two tungsten cruise ballast mass devices (CBMD) and fragments of the cruise stage formed meter‐scale craters north‐west of Jezero crater, in one of the sinuous ...
A. J. Sokołowska +4 more
wiley +1 more source
Climate stressor projections inform adaptation needs in South Asian oilseed systems. [PDF]
Barik A +6 more
europepmc +1 more source
Abstract Recent work has demonstrated that convection‐permitting models often produce a greater number of precipitating convective cells compared to radar observations. Congestus‐depth cells contribute most to the bias, which are colloquially termed “popcorn convection.” This study explores warm‐phase microphysical contributions to the bias using ...
McKenna W. Stanford +7 more
wiley +1 more source

