Results 61 to 70 of about 86,136 (325)

Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.

Proceedings of the National Academy of Sciences of the United States of America, 1979
Use of the specific-locus test to measure the frequency of transmitted gene mutations induced in mouse spermatogonia has shown ethylnitrosourea to be by far the most potent mutagen yet discovered in the mouse.
W. Russell, E. Kelly, P. Hunsicker, J. Bangham, S. Maddux, E. Phipps   +5 more
semanticscholar   +1 more source

Mutagenic Effectiveness and Efficiency of Gamma Rays and Ethyl Methanesulphonate in Pea (Pisum sativum L.) [PDF]

, 2011
Mutagenic effectiveness is a measure of the frequency of mutations induced by unit dose of a mutagen while efficiency gives the proportion of mutations in relation to other associated undesirable biological effects such as lethality, pollen sterility and
Pachkore3 and R. A. Satpute4, G. S. Dhulgande1*, D.A. Dhale2, G. L.
core   +2 more sources

Sidestream tobacco smoke is a male germ cell mutagen

Proceedings of the National Academy of Sciences of the United States of America, 2011
Active cigarette smoking increases oxidative damage, DNA adducts, DNA strand breaks, chromosomal aberrations, and heritable mutations in sperm. However, little is known regarding the effects of second-hand smoke on the male germ line.
F. Marchetti, A. Rowan‐Carroll, Andrew Williams, Aris A. Polyzos, M. L. Berndt-Weis, C. Yauk   +5 more
semanticscholar   +1 more source

Association of Meat Intake and Meat-Derived Mutagen Exposure with the Risk of Colorectal Polyps by Histologic Type

Cancer Prevention Research, 2011
The association of meat intake and meat-derived mutagens with colorectal tumor risk remains unclear. We evaluated this hypothesis in a large colonoscopy-based case–control study.
Zhenming Fu, M. Shrubsole, W. Smalley, Huiyun Wu, Zhi Chen, Y. Shyr, R. Ness, W. Zheng   +7 more
semanticscholar   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer. [PDF]

PLoS Computational Biology, 2017
There is compelling biological data to suggest that cancer arises from a series of mutations in single target cells, resulting in defects in cell renewal and differentiation processes which lead to malignancy.
Mark P Little, Jolyon H Hendry
doaj   +1 more source

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Devaux, Alain, Ferrier, Vincent, Gauthier, Laury, Jourdain, Marie-José, Mailhes, Corinne, Mouchet, Florence, Triffault, Gaëlle   +6 more
core   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

The mutagenicity and anti-mutagenicity effect of aqueous leaves extract of Vinca rosea by bacterial system (Part one)

مجلة مركز بحوث التقنيات الاحيائية, 2015
This study was carried out in order to determine the toxic, mutagenic and anti-mutagenic effects for aqueous extract of Vinca rosea dried leaves against the mutagenic effect of Methotrexate (MTX) as a chemical mutagen and Ultra Violet rays (UV) as a ...
Ali Hafedh Abbas Abbas, Likaa Hasoun Sagban Sagban , Hind Hussein Obaid Obaid, Ishrak Abdul Ameer Abdul Ameer, Rasha Hussein Kubba Kubba, Shaymaa Adnan Ez-Aldeen Ez-Aldeen   +5 more
doaj   +1 more source

EFFECT OF GRADEN CRESS (Lepidium sativum) ON CHROMOSOMAL ABERRATIONS AND ITS ANTI - EFFECT ON INDUCTION OF CHROMOSOMAL ABERRATIONS IN WHITE MICE BONE MARROW CELLS USING SHORT – TERM TESTS [PDF]

Mesopotamia Journal of Agriculture, 2009
Effect of garden cress Lepidium sativum (a cruciferous plant) on induction of chromosomal aberrations in bone marrow cells of white mice was studied , in addition to its effect to reverse the chromosomal aberrations induced by drug cyclophosphamide (Cp).
Ilham A. Khalaf
doaj   +1 more source