Results 61 to 70 of about 90,461 (311)

EFFECT OF GARDEN CRESS (LEPIDIUM SATIVUM ) ON MITOTIC INDEX AND FORMATION OF MICRONUCLEI IN WHITE MICE BONE MARROW CELLS [PDF]

Mesopotamia Journal of Agriculture, 2009
The effect of garden cress ( Lepidium sativum ) on mitotic index (MI) and formation of micronuclei (Mn) in bone marrow cells of white mice was studied , in addition to the study of the counter effect of plant juice on MI disruption and Mn induction by ...
Ilham A. Khalaf
doaj   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Potential Benefits of Sequential Inhibitor-Mutagen Treatments of RNA Virus Infections

PLoS Pathogens, 2009
Lethal mutagenesis is an antiviral strategy consisting of virus extinction associated with enhanced mutagenesis. The use of non-mutagenic antiviral inhibitors has faced the problem of selection of inhibitor-resistant virus mutants.
C. Perales, R. Agudo, Héctor Tejero, S. Manrubia, E. Domingo   +4 more
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America, 1991
Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated for use as a short-term, in vivo mutagenesis assay. The gene is recovered from the treated mice by exposing mouse genomic DNA to in vitro packaging extracts and ...
S. Kohler, Provost Gs, A. Fieck, P. L. Kretz, W. Bullock, J. Sorge, D. Putman, J. Short   +7 more
semanticscholar   +1 more source

Squamous cell carcinoma of the dorsal hands and feet after repeated exposure to ultraviolet nail lamps [PDF]

, 2020
Gel nails are a common artificial nail option. Ultraviolet (UV) nail lamps are commonly used to cure gel nails. Ultraviolet A radiation is a known mutagen that penetrates into the nail bed.
Curtis, Julia, Freeman, Caleb, Hull, Christopher, Sontheimer, Richard   +3 more
core  

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Chromosomal rearrangements caused by gamma-irradiation in winter wheat cells

Biosystems Diversity, 2017
In this article we report the results of our investigation into several cytogenetic parameters of variability in mutation induction of modern winter wheat varieties and some connections between the means of cytogenetic indices and different doses of ...
M. M. Nazarenko, O. O. Izhboldin
doaj   +1 more source

EFFECT OF ROCKET JUICE (ERUCA SATIVA ) ON MITOTIC INDEX AND FORMATION OF MICRONUCLEI IN FEMUR BONE MARROW CELLS OF WHITE MICE [PDF]

Mesopotamia Journal of Agriculture, 2008
The effect of orally administered rocket leafs juice on the mitotic index (MI) and micronuclei (Mn) formation was studied in white mice bone marrow . The effect of juice to retarded the abnormalities induced by cyclophosphamide (Cp) administered orally ...
Ilham A. Khalaf
doaj   +1 more source

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury, Jean, Séverine, Laplanche, Christophe, Merlina, Georges, Pinelli, Eric, Polard, Thierry   +5 more
core   +2 more sources