Results 71 to 80 of about 90,461 (311)
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl+14 more
wiley +1 more source
Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study.
UNLABELLED Given the high incidence of breast cancer and that more than half of cases remain unexplained, the need to identify risk factors for breast cancer remains. Deficiencies in DNA repair capacity have been associated with cancer risk.
O. Kosti+9 more
semanticscholar +1 more source
Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Shaofei Zhang+23 more
wiley +1 more source
Aromatic amines, N-nitroso compounds and heterocyclic amines are suspected human pancreatic carcinogens. Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens.
Hideo Suzuki+11 more
semanticscholar +1 more source
The influence of radio-mimetic chemical mutagen on the chromosomal complex of winter wheat cells
In this article we report the results of our investigation of cytogenetic parameters of changes in the chromosomal complex of new Ukrainian winter wheat varieties and some relationships between values of cytological indexes and different concentrations ...
M. M. Nazarenko
doaj +1 more source
Mutation Breeding in Ornamentals
The promising possibilities of mutation breeding in ornamental plants have led to a great interest in effective mutagenic treatment protocols for various species.
Killian Melsen+2 more
doaj +1 more source
ABSTRACT We constructed a catalog of mutational sites in the tdk gene of Escherichia coli that consists of 378 different base pair substitutions at 245 different sites (base pairs). This allows us to examine the tendency of different sub‐regions of the gene to be more or less prone to mutations when compared with other sub‐regions.
Katherine Douglas+10 more
wiley +1 more source
Anti-genotoxic effect of aloe vera gelR on the mutagenic action of ethyl methanesulfonate [PDF]
The antimutagenic effect of aloe vera gelR was investigated using the Drosophila sex-linked recessive lethal test (or SLRL test). In this assay, 3-day-old adults were treated with a direct-acting mutagen - ethyl methanesulfonate (EMS), which was the ...
Stanić Snežana
doaj +1 more source
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas+8 more
wiley +1 more source
Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation [PDF]
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity.
A Gil-Izquierdo+53 more
core +3 more sources