Results 71 to 80 of about 86,136 (325)

Mussel eggs as indicators of mutagen exposure in coastal and estuarine environments [PDF]

, 1994
The aim of this study was to develop a short-term genotoxicity assay for monitoring the marine environment for mutagens. Based on the developing eggs and embryos of the marine mussel Mytilus edulis, an important pollution indicator species, the test ...
Dixon, D.R., Pascoe, P.L
core  

Cell transformation assays for prediction of carcinogenic potential: State of the science and future research needs [PDF]

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
A. D. Scott, A. Poth, A. Sakai, Asada, Ashby, Bernardi, Berwald, Berwald, Boehm, Campisi, Carmichael, Cohen, Dolma, Evan, F. L. Martin, Farmer, H. Yasaei, Haga, Huberman, Isfort, Isfort, Isfort, J. S. Harvey, K. Pant, K. Sasaki, Kelly, Kerckaert, Kirkland, Kirkland, L. M. Schechtman, Layer, LeBoeuf, LeBoeuf, M. J. Aardema, M. R. O'Donovan, Martin, Martinez-Lopez de Castro, Mauthe, McCarvill, N. Tanaka, Newbold, Newbold, P. L. Carmichael, Pang, Pant, Pant, Pfuhler, R. F. Newbold, R. R. Shen, Robinson, Russo, S. Creton, Sakai, Sakai, Schechtman, Schinzel, Shen, Sheng, Stampfer, Stinghen, Syed, Trevisan, Visvader, Walsh, Zakut, Zhao   +65 more
core   +2 more sources

Size matters: sequential mutations in tumorigenesis may reflect the stochastic effect of mutagen target sizes.

Genes & cancer, 2011
We tallied the number of possible mutant amino acids in proteins thought to be inactivated early in tumorigenesis and in proteins thought to be inactivated late in tumorigenesis, respectively. Proteins thought to be inactivated early in tumorigenesis, on
K. Long, Toaa Abuelenen, L. Pava, Maya Bastille, G. Blanck   +4 more
semanticscholar   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

EFFECT OF GARDEN CRESS (LEPIDIUM SATIVUM ) ON MITOTIC INDEX AND FORMATION OF MICRONUCLEI IN WHITE MICE BONE MARROW CELLS [PDF]

Mesopotamia Journal of Agriculture, 2009
The effect of garden cress ( Lepidium sativum ) on mitotic index (MI) and formation of micronuclei (Mn) in bone marrow cells of white mice was studied , in addition to the study of the counter effect of plant juice on MI disruption and Mn induction by ...
Ilham A. Khalaf
doaj   +1 more source

Potential Benefits of Sequential Inhibitor-Mutagen Treatments of RNA Virus Infections

PLoS Pathogens, 2009
Lethal mutagenesis is an antiviral strategy consisting of virus extinction associated with enhanced mutagenesis. The use of non-mutagenic antiviral inhibitors has faced the problem of selection of inhibitor-resistant virus mutants.
C. Perales, R. Agudo, Héctor Tejero, S. Manrubia, E. Domingo   +4 more
semanticscholar   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Use of high throughput sequencing to observe genome dynamics at a single cell level [PDF]

, 2009
With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced several genomes of Escherichia coli from colonies obtained after chemical mutagenesis and observed ...
arxiv   +1 more source

The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]

, 2018
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S, Gou, Liangke, Kruglyak, Leonid   +2 more
core   +1 more source

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America, 1991
Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated for use as a short-term, in vivo mutagenesis assay. The gene is recovered from the treated mice by exposing mouse genomic DNA to in vitro packaging extracts and ...
S. Kohler, Provost Gs, A. Fieck, P. L. Kretz, W. Bullock, J. Sorge, D. Putman, J. Short   +7 more
semanticscholar   +1 more source