Results 71 to 80 of about 90,461 (311)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl   +14 more
wiley   +1 more source

Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study.

open access: yesCarcinogenesis, 2010
UNLABELLED Given the high incidence of breast cancer and that more than half of cases remain unexplained, the need to identify risk factors for breast cancer remains. Deficiencies in DNA repair capacity have been associated with cancer risk.
O. Kosti   +9 more
semanticscholar   +1 more source

Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Shaofei Zhang   +23 more
wiley   +1 more source

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer

open access: yesCarcinogenesis, 2008
Aromatic amines, N-nitroso compounds and heterocyclic amines are suspected human pancreatic carcinogens. Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens.
Hideo Suzuki   +11 more
semanticscholar   +1 more source

The influence of radio-mimetic chemical mutagen on the chromosomal complex of winter wheat cells

open access: yesRegulatory Mechanisms in Biosystems, 2017
In this article we report the results of our investigation of cytogenetic parameters of changes in the chromosomal complex of new Ukrainian winter wheat varieties and some relationships between values of cytological indexes and different concentrations ...
M. M. Nazarenko
doaj   +1 more source

Mutation Breeding in Ornamentals

open access: yesHortScience, 2021
The promising possibilities of mutation breeding in ornamental plants have led to a great interest in effective mutagenic treatment protocols for various species.
Killian Melsen   +2 more
doaj   +1 more source

Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT We constructed a catalog of mutational sites in the tdk gene of Escherichia coli that consists of 378 different base pair substitutions at 245 different sites (base pairs). This allows us to examine the tendency of different sub‐regions of the gene to be more or less prone to mutations when compared with other sub‐regions.
Katherine Douglas   +10 more
wiley   +1 more source

Anti-genotoxic effect of aloe vera gelR on the mutagenic action of ethyl methanesulfonate [PDF]

open access: yesArchives of Biological Sciences, 2007
The antimutagenic effect of aloe vera gelR was investigated using the Drosophila sex-linked recessive lethal test (or SLRL test). In this assay, 3-day-old adults were treated with a direct-acting mutagen - ethyl methanesulfonate (EMS), which was the ...
Stanić Snežana
doaj   +1 more source

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

open access: yesChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas   +8 more
wiley   +1 more source

Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation [PDF]

open access: yes, 2012
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity.
A Gil-Izquierdo   +53 more
core   +3 more sources

Home - About - Disclaimer - Privacy