Results 161 to 170 of about 352,449 (219)
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Methods, 2004
Mutagenesis represents a powerful methodology for the analysis of protein structural and functional relationships and dissection of complex protein-protein interactions. The suicide substrate-like inhibitory mechanism of the proteins of the serpin superfamily offers unique challenges for the design of mutagenesis studies.
Toni M, Antalis, Daniel A, Lawrence
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Mutagenesis represents a powerful methodology for the analysis of protein structural and functional relationships and dissection of complex protein-protein interactions. The suicide substrate-like inhibitory mechanism of the proteins of the serpin superfamily offers unique challenges for the design of mutagenesis studies.
Toni M, Antalis, Daniel A, Lawrence
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Environmental Mutagenesis, 1981
AbstractI would first like to thank the Environmental Mutagen Society for honoring me with its 1980 award; I also would like to take this opportunity to acknowledge all the people who have worked with me and helped me since I started my work in mutagenesis in 1953.
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AbstractI would first like to thank the Environmental Mutagen Society for honoring me with its 1980 award; I also would like to take this opportunity to acknowledge all the people who have worked with me and helped me since I started my work in mutagenesis in 1953.
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Annual Review of Nutrition, 2008
Diet-related mutagenesis plays an etiologic role in chronic diseases, including cardiovascular disease and cancer. Many dietary mutagens are DNA reactive, leading to distinct spectra of base-pair substitution mutations and structural chromosome changes.
Lynnette R, Ferguson, Martin, Philpott
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Diet-related mutagenesis plays an etiologic role in chronic diseases, including cardiovascular disease and cancer. Many dietary mutagens are DNA reactive, leading to distinct spectra of base-pair substitution mutations and structural chromosome changes.
Lynnette R, Ferguson, Martin, Philpott
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Environmental and Molecular Mutagenesis, 1989
Our understanding of mechanisms of mutation, which has expanded greatly in the past few decades, served as the original impetus to the formation of the Environmental Mutagen Society. The advances in genetics and chemistry that have conditioned our present degree of knowledge are here catalogued and the future is predicted.
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Our understanding of mechanisms of mutation, which has expanded greatly in the past few decades, served as the original impetus to the formation of the Environmental Mutagen Society. The advances in genetics and chemistry that have conditioned our present degree of knowledge are here catalogued and the future is predicted.
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Biological Reviews, 1949
SummaryThe general methodological requirements for work with chemical mutagens are the same as for general mutation work, with special emphasis on questions of concentration, penetration, possible indirect or delayed effect, differences in susceptibility between individuals, strains and species.
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SummaryThe general methodological requirements for work with chemical mutagens are the same as for general mutation work, with special emphasis on questions of concentration, penetration, possible indirect or delayed effect, differences in susceptibility between individuals, strains and species.
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Programmed Mutagenesis Is Universal
Theory of Computing Systems, 2002zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Julia Khodor, David K. Gifford
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2007
Localized mutagenesis can be used to obtain mutants in genes of interest based on linkage to selectable markers. Mutagens diethylsulfate and hydroxylamine are used to obtain predominantly transition mutations in the DNA either by whole chromosomal mutagenesis or mutagenesis of DNA isolated as purified plasmid or packaged in transducing phage particles.
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Localized mutagenesis can be used to obtain mutants in genes of interest based on linkage to selectable markers. Mutagens diethylsulfate and hydroxylamine are used to obtain predominantly transition mutations in the DNA either by whole chromosomal mutagenesis or mutagenesis of DNA isolated as purified plasmid or packaged in transducing phage particles.
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2014
Transposon-based mutagenesis of bacterial genomes is a powerful method to identify genetic elements that control specific phenotypes. The most frequently used transposon tools in Pseudomonas aeruginosa are based either on Himar1 mariner or Tn5 transposases, both of which have been used to generate nonredundant mutant libraries in P. aeruginosa. Here we
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Transposon-based mutagenesis of bacterial genomes is a powerful method to identify genetic elements that control specific phenotypes. The most frequently used transposon tools in Pseudomonas aeruginosa are based either on Himar1 mariner or Tn5 transposases, both of which have been used to generate nonredundant mutant libraries in P. aeruginosa. Here we
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2007
Forward genetics in Drosophila has profoundly affected our understanding of circadian rhythms in this organism and, more generally, in the animal kingdom. Most Drosophila pacemaker genes were discovered through the isolation of gene variants affecting the free-running period of the circadian pacemaker. There are different ways to mutagenize flies.
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Forward genetics in Drosophila has profoundly affected our understanding of circadian rhythms in this organism and, more generally, in the animal kingdom. Most Drosophila pacemaker genes were discovered through the isolation of gene variants affecting the free-running period of the circadian pacemaker. There are different ways to mutagenize flies.
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2013
Genome-wide association screens (GWASs) for a large number of human genetic diseases generate novel hypotheses about familial and sporadic mutations. Gene targeting in embryonic stem cell (ESC), along with the new repertoire of zinc-finger nucleases (ZFNs), TAL effector nucleases (TALENs) and recombinase-mediated cassette exchange (RMCE) techniques ...
Floss, T., Guimera, J.
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Genome-wide association screens (GWASs) for a large number of human genetic diseases generate novel hypotheses about familial and sporadic mutations. Gene targeting in embryonic stem cell (ESC), along with the new repertoire of zinc-finger nucleases (ZFNs), TAL effector nucleases (TALENs) and recombinase-mediated cassette exchange (RMCE) techniques ...
Floss, T., Guimera, J.
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