Results 181 to 190 of about 31,259 (226)
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Mutagenicity of oxytetracycline
Mutation Research/Genetic Toxicology, 1983Oxytetracycline hydrochloride, potassium nitrite and a combination of this antibiotic with the nitrite were tested for their mutagenicity in the host-mediated assay with mice as the host animals. The Salmonella typhimurium strain used was his G46. The bacteria were injected intraperitoneally, and the test compounds were administered by a stomach tube ...
Jadwiga Koziorowska +3 more
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On the mutagenicity of nitroimidazoles
Mutation Research/Reviews in Genetic Toxicology, 1981Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
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Modulation of mutagenicity by phosphorylation of mutagen-metabolizing enzymes
Archives of Biochemistry and Biophysics, 2004In this Minireview, we discuss our findings on phosphorylation of cytochromes P450 (CYP) and influence of this modification on metabolic toxification and/or detoxification of a variety of mutagens. We show that phosphorylation drastically interferes with the mutagenicity of several classes of compounds which are of high human relevance (cytostatic ...
Barbara Oesch-Bartlomowicz, Franz Oesch
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, 2011
Mutation induction is considered as an effective way to enrich plant genetic variation, particularly for traits with a very low level of genetic variation. The objectives of this study were to evaluate the effect of different dosages of chemical mutagens
P. Nathan +4 more
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Mutation induction is considered as an effective way to enrich plant genetic variation, particularly for traits with a very low level of genetic variation. The objectives of this study were to evaluate the effect of different dosages of chemical mutagens
P. Nathan +4 more
semanticscholar +1 more source
Germ cell mutagens: Risk assessment challenges in the 21st century
Environmental and Molecular Mutagenesis, 2010Heritable mutations may result in a wide variety of detrimental outcomes, from embryonic lethality to genetic disease in the offspring. Despite this, today's commonly used test batteries do not include assays for germ cell mutation.
Tim Singer, C. Yauk
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Modulation of mutagenicity of various mutagens by lignin derivatives
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2003The effect of lignin on cytotoxicity, mutagenicity and SOS response induced by 4-nitroquinoline-N-oxide (4NQO), 3-(5-nitro-2-furyl)acrylic acid (5NFAA), 2-nitrofluorene (2NF) as well as hydrogen peroxide was investigated in bacterial assay systems, i.e. the Ames test with Salmonella typhimurium TA98, TA100, TA102 and the SOS chromotest with Escherichia
Božena Košíková +1 more
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Anti-mutagenicity of catechin against environmental mutagens
Mutagenesis, 1988Catechu is the non-mutagenic component of betel quid. We have tested catechu extract and catechin for anti-mutagenic activity in Salmonella typhimurium strain TA98 against environmental mutagens relevant to India. Catechu extract, as well as catechin, shows a dose-dependent decrease in the mutagenicity of tobacco and masheri extracts, and bidi and ...
Sumati V. Bhide, Moolky Nagabhushan
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Mutagen and anti-mutagen in ginger, Zingiber officinale
Mutation Research Letters, 1982When rhizome juice of ginger, zingiber officinale, was added to a solution of 2(2-furyl)-3(5-nitro-2-fury)acryl amide (AF2) or N-methyl-N'-nitro-N-nitrosoguanidine (NTG), mutagenesis by these chemicals was markedly increased. As a result of the component fractionation of the ginger juice, it was found that [6]-gingerol was a potent mutagen.
Takeshi Yamamoto, Hakobu Nakamura
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Mutation Research/Genetic Toxicology, 1978
The commercially available volatile anesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether) which contains the stabilizer N-phenyl-1-napthylamine, was tested for mutagenicity using four strains of S. typhimurium, TA1535, TA1537, TA98 and TA100, and one strain of E. coli, WP2. In addition, purified fluroxene; N-phenyl-1-napthylamine; trifluoroethanol, a
J M, Baden +4 more
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The commercially available volatile anesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether) which contains the stabilizer N-phenyl-1-napthylamine, was tested for mutagenicity using four strains of S. typhimurium, TA1535, TA1537, TA98 and TA100, and one strain of E. coli, WP2. In addition, purified fluroxene; N-phenyl-1-napthylamine; trifluoroethanol, a
J M, Baden +4 more
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Mutation Research/Reviews in Genetic Toxicology, 1975
Seventeen different reports are available dealing with the mutagenic effects of saccharin. Many of these are short abstracts, carrying incomplete information. Mainly tested as its sodium salt, saccharin has been found to be weakly mutagenic in Salmonella at very high doses, in Drosophila at moderate doses, and in mice at moderate to high doses.
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Seventeen different reports are available dealing with the mutagenic effects of saccharin. Many of these are short abstracts, carrying incomplete information. Mainly tested as its sodium salt, saccharin has been found to be weakly mutagenic in Salmonella at very high doses, in Drosophila at moderate doses, and in mice at moderate to high doses.
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