Results 191 to 200 of about 24,106 (233)

On the mutagenicity of nitroimidazoles

Mutation Research/Reviews in Genetic Toxicology, 1981
Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
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Mutagenicity of oxytetracycline

Mutation Research/Genetic Toxicology, 1983
Oxytetracycline hydrochloride, potassium nitrite and a combination of this antibiotic with the nitrite were tested for their mutagenicity in the host-mediated assay with mice as the host animals. The Salmonella typhimurium strain used was his G46. The bacteria were injected intraperitoneally, and the test compounds were administered by a stomach tube ...
D, Blitek, K, Pieńkowska, H, Gajcy, J, Koziorowska   +3 more
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Modulation of mutagenicity by phosphorylation of mutagen-metabolizing enzymes

Archives of Biochemistry and Biophysics, 2004
In this Minireview, we discuss our findings on phosphorylation of cytochromes P450 (CYP) and influence of this modification on metabolic toxification and/or detoxification of a variety of mutagens. We show that phosphorylation drastically interferes with the mutagenicity of several classes of compounds which are of high human relevance (cytostatic ...
Barbara, Oesch-Bartlmowicz, Franz, Oesch
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Anti-mutagenicity of catechin against environmental mutagens

Mutagenesis, 1988
Catechu is the non-mutagenic component of betel quid. We have tested catechu extract and catechin for anti-mutagenic activity in Salmonella typhimurium strain TA98 against environmental mutagens relevant to India. Catechu extract, as well as catechin, shows a dose-dependent decrease in the mutagenicity of tobacco and masheri extracts, and bidi and ...
M, Nagabhushan, S V, Bhide
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Mutagen and anti-mutagen in ginger, Zingiber officinale

Mutation Research Letters, 1982
When rhizome juice of ginger, zingiber officinale, was added to a solution of 2(2-furyl)-3(5-nitro-2-fury)acryl amide (AF2) or N-methyl-N'-nitro-N-nitrosoguanidine (NTG), mutagenesis by these chemicals was markedly increased. As a result of the component fractionation of the ginger juice, it was found that [6]-gingerol was a potent mutagen.
H, Nakamura, T, Yamamoto
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Metals as Mutagens

1978
A number of metals are mutagenic in bacteria or phage. These include compounds of arsenic, chromium, copper, iron, manganese, molybdenum, platinum, and selenium. Compounds containing alumium, antimony, arsenic, cadmium, copper, lead, mercury, nickel, and tellium have been shown to induce chromosomal aberrations or abnormal cell divisions in animal or ...
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The mutagenicity of saccharin

Mutation Research/Reviews in Genetic Toxicology, 1975
Seventeen different reports are available dealing with the mutagenic effects of saccharin. Many of these are short abstracts, carrying incomplete information. Mainly tested as its sodium salt, saccharin has been found to be weakly mutagenic in Salmonella at very high doses, in Drosophila at moderate doses, and in mice at moderate to high doses.
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Mutagenicity of ethyleneimine

Mutation Research/Reviews in Genetic Toxicology, 1990
Verschaeve, Luc, Volders, Micheline
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Mutagens in commercial food processing and its microbial transformation

Food Science and Biotechnology, 2023
Sarat Babu Imandi
exaly  

MUTAGENICITY OF METRONIDAZOLE

The Lancet, 1979
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