Results 181 to 190 of about 26,614 (228)
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Mutagenicity of proanthocyanidins
Food and Chemical Toxicology, 1987Several procyanidins with different degrees of polymerization (dimers, a trimer and a polymer) and extracted from different natural sources were found to be non-mutagenic in the Salmonella mutagenesis assay system. A mutagenic impurity in procyanidin B-4 was isolated by means of reversed-phase high-performance liquid chromatography (HPLC) and ...
C L, Yu, B, Swaminathan
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Mutation Research/Genetic Toxicology, 1978
The commercially available volatile anesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether) which contains the stabilizer N-phenyl-1-napthylamine, was tested for mutagenicity using four strains of S. typhimurium, TA1535, TA1537, TA98 and TA100, and one strain of E. coli, WP2. In addition, purified fluroxene; N-phenyl-1-napthylamine; trifluoroethanol, a
J M, Baden +4 more
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The commercially available volatile anesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether) which contains the stabilizer N-phenyl-1-napthylamine, was tested for mutagenicity using four strains of S. typhimurium, TA1535, TA1537, TA98 and TA100, and one strain of E. coli, WP2. In addition, purified fluroxene; N-phenyl-1-napthylamine; trifluoroethanol, a
J M, Baden +4 more
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A Mutagen is a Mutagen, Not Necessarily a Carcinogen
1986A largely unspoken but underlying assumption that has been made by authors throughout these proceedings is that processes involved in antimutagenesis are related to anticarcinogenesis, a corollary of the somatic mutation theory of carcinogenesis.
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Carcinogenesis, 1989
Solutions of several promutagens or of non-genotoxic carcinogens were exposed to sunlight or to artificial sources of UV or fluorescent light, under various experimental conditions. Irradiation resulted in the oxygen-mediated formation of direct-acting mutagenic and DNA-damaging photoproducts in bacteria, with evident structure-activity relationship ...
DE FLORA, SILVIO +4 more
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Solutions of several promutagens or of non-genotoxic carcinogens were exposed to sunlight or to artificial sources of UV or fluorescent light, under various experimental conditions. Irradiation resulted in the oxygen-mediated formation of direct-acting mutagenic and DNA-damaging photoproducts in bacteria, with evident structure-activity relationship ...
DE FLORA, SILVIO +4 more
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Nature, 1972
THERE have been several conflicting reports on the genetic effects of Dichlorvos (2,2-dichlorovinyl dimethyl phosphate), which is the active ingredient of Shell's pesticide, ‘Vapona’.
M J, Ashwood-Smith, J, Trevino, R, Ring
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THERE have been several conflicting reports on the genetic effects of Dichlorvos (2,2-dichlorovinyl dimethyl phosphate), which is the active ingredient of Shell's pesticide, ‘Vapona’.
M J, Ashwood-Smith, J, Trevino, R, Ring
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On the mutagenicity of nitroimidazoles
Mutation Research/Reviews in Genetic Toxicology, 1981Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
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Mutagenicity of oxytetracycline
Mutation Research/Genetic Toxicology, 1983Oxytetracycline hydrochloride, potassium nitrite and a combination of this antibiotic with the nitrite were tested for their mutagenicity in the host-mediated assay with mice as the host animals. The Salmonella typhimurium strain used was his G46. The bacteria were injected intraperitoneally, and the test compounds were administered by a stomach tube ...
D, Blitek +3 more
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Modulation of mutagenicity by phosphorylation of mutagen-metabolizing enzymes
Archives of Biochemistry and Biophysics, 2004In this Minireview, we discuss our findings on phosphorylation of cytochromes P450 (CYP) and influence of this modification on metabolic toxification and/or detoxification of a variety of mutagens. We show that phosphorylation drastically interferes with the mutagenicity of several classes of compounds which are of high human relevance (cytostatic ...
Barbara, Oesch-Bartlmowicz, Franz, Oesch
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Anti-mutagenicity of catechin against environmental mutagens
Mutagenesis, 1988Catechu is the non-mutagenic component of betel quid. We have tested catechu extract and catechin for anti-mutagenic activity in Salmonella typhimurium strain TA98 against environmental mutagens relevant to India. Catechu extract, as well as catechin, shows a dose-dependent decrease in the mutagenicity of tobacco and masheri extracts, and bidi and ...
M, Nagabhushan, S V, Bhide
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Mutagen and anti-mutagen in ginger, Zingiber officinale
Mutation Research Letters, 1982When rhizome juice of ginger, zingiber officinale, was added to a solution of 2(2-furyl)-3(5-nitro-2-fury)acryl amide (AF2) or N-methyl-N'-nitro-N-nitrosoguanidine (NTG), mutagenesis by these chemicals was markedly increased. As a result of the component fractionation of the ginger juice, it was found that [6]-gingerol was a potent mutagen.
H, Nakamura, T, Yamamoto
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