Results 11 to 20 of about 44,639 (231)
Random Mutagenesis in Porphyromonas gingivalis Enables Isolation of Mutants With Enhanced Secreted Protease Activity. [PDF]
Mol Oral MicrobiolABSTRACT Porphyromonas gingivalis is a key pathogen in periodontitis, with secreted proteases as major virulence factors. We developed a screening method to generate and identify P. gingivalis mutants with elevated protease activity. Mutations were induced using the mutagens 2,6‐diaminopurine (2,6‐DAP) or ethyl methanesulfonate (EMS), and the ...
Nakabayashi T, Yuhara S, Tanaka K.
europepmc +2 more sources
Human urinary mutagenicity after wood smoke exposure during traditional temazcal use. [PDF]
, 2014 In Central America, the traditional temazcales or wood-fired steam baths, commonly used by many Native American populations, are often heated by wood fires with little ventilation, and this use results in high wood smoke exposure.
HOLLAND, Nina +8 more
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Induced Mutations Unleash the Potentials of Plant Genetic Resources for Food and Agriculture
Agronomy, 2013 The options for increasing food production by at least 70% over the next four decades so as to keep pace with a rapidly increasing human population are bedeviled by erratic climatic conditions, depleted arable lands, dwindling water resources and by the ...
Chikelu Mba
doaj +1 more source
Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]
, 2017 Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena +9 more
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Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022 The development of effective and safe therapeutic agents using 1,2,4-triazole derivatives is gaining momentum in today’s conditions. The value of such drugs is determined by the rapid and prolonged biological action, which is not accompanied by abrupt ...
I. V. Bushuieva +3 more
doaj +1 more source
PLoS ONE, 2023 Replication errors influence mutations, and thus, lifetime cancer risk can be explained by the number of stem-cell divisions. Additionally, mutagens also affect cancer risk, for instance, high-dose radiation exposure increases lifetime cancer risk ...
Kouki Uchinomiya, Masanori Tomita
doaj +1 more source
Assessment of genotoxic and mutagenic effects of food products by bioassay methods
Теория и практика переработки мяса, 2021 The current state of studies on application and safety of food additives in various technologies for food production is examined. Considerable attention should be given to studies dedicated to analysis of food safety criteria due to a possibility of ...
M. V. Zaytseva
doaj +1 more source
In-silico Predictive Mutagenicity Model Generation Using Supervised Learning Approaches [PDF]
, 2011 With the advent of High Throughput Screening techniques, it is feasible to filter possible leads from a mammoth chemical space that can act against a particular target and inhibit its action.
Abhik Seal +4 more
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The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time
Frontiers in Genetics, 2021 During life, the DNA of our cells is continuously exposed to external damaging processes. Despite the activity of various repair mechanisms, DNA damage eventually results in the accumulation of mutations in the genomes of our cells.
Axel Rosendahl Huber +5 more
doaj +1 more source
Antimutagenic and antioxidant activity of a protein fraction from aerial parts of Urtica dioica [PDF]
, 2014 Context: Urtica dioica L. (Urticaceae), stinging nettle, has been employed as a folklore remedy for a wide spectrum of ailments, including urinary disorders, prostatic hyperplasia, and liver diseases.
DI GIACOMO, Silvia +6 more
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