Results 211 to 220 of about 48,990 (266)
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Mutagenicity of sulphonylureas
Mutation Research/Genetic Toxicology, 1980The 11 derivatives of beta-cytotropic sulphonylureas commonly used in the treatment of diabetes mellitus were tested in vivo in the highly sensitive sister-chromatid exchange test. Chlorpropamide and tolbutamide gave a positive reaction with a clear dose-response in Chinese hamsters and mice.
Ruth Münzner, H.W. Renner
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On the mutagenicity of nitrofurans
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1974Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
Donna Voutsinos, D.R. McCalla
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Structure-activity relationships and design of viral mutagens and application to lethal mutagenesis.
Journal of Medicinal Chemistry, 2013While mutation is the driving force behind evolution, most mutations are detrimental; therefore, elevating the mutation rate of a virus should diminish fitness.
L. Bonnac, L. Mansky, S. Patterson
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Chemical Research in Toxicology, 2013
Caffeine is one of the most important biologically active food components. In this article, we demonstrate that caffeine and other methylxanthines significantly reduce the mutagenic activity of two food-derived heterocyclic aromatic amines, Trp-P-1 and ...
A. Woziwodzka +4 more
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Caffeine is one of the most important biologically active food components. In this article, we demonstrate that caffeine and other methylxanthines significantly reduce the mutagenic activity of two food-derived heterocyclic aromatic amines, Trp-P-1 and ...
A. Woziwodzka +4 more
semanticscholar +1 more source
Nature, 1972
THERE have been several conflicting reports on the genetic effects of Dichlorvos (2,2-dichlorovinyl dimethyl phosphate), which is the active ingredient of Shell's pesticide, ‘Vapona’.
J. Trevino, M. J. Ashwood-Smith, R. Ring
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THERE have been several conflicting reports on the genetic effects of Dichlorvos (2,2-dichlorovinyl dimethyl phosphate), which is the active ingredient of Shell's pesticide, ‘Vapona’.
J. Trevino, M. J. Ashwood-Smith, R. Ring
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Mutagenicity of proanthocyanidins
Food and Chemical Toxicology, 1987Several procyanidins with different degrees of polymerization (dimers, a trimer and a polymer) and extracted from different natural sources were found to be non-mutagenic in the Salmonella mutagenesis assay system. A mutagenic impurity in procyanidin B-4 was isolated by means of reversed-phase high-performance liquid chromatography (HPLC) and ...
C.-L. Yu, B. Swaminathan
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Toxicology, 1978
Incubation of Salmonella typhimurium strains in an atmosphere of 0.2% gaseous acrylonitrile increased the numbers of his+ revertants/plate only in the presence of a fortified S9 liver fraction. The mutagenic effect was particularly pronounced with strains TA1530, TA1535 and TA1950 and much weaker with strains TA100, TA98 and TA1978.
F. Poncelet +3 more
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Incubation of Salmonella typhimurium strains in an atmosphere of 0.2% gaseous acrylonitrile increased the numbers of his+ revertants/plate only in the presence of a fortified S9 liver fraction. The mutagenic effect was particularly pronounced with strains TA1530, TA1535 and TA1950 and much weaker with strains TA100, TA98 and TA1978.
F. Poncelet +3 more
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Mutagenicity of radiations and chemical mutagens in Sorghum
Theoretical and Applied Genetics, 1970A comparative study on the relative mutagenicity of radiations (X-and gamma rays) and chemical mutagens (EMS, MMS, dES and NEU) in inducing chlorophyll, viable and total mutations was made on three cultivated varieties (Co. 11, Co. 12 and Co. 18) of Eu-Sorghum. A critical comparison of the chlorophyll, viable and total mutations shows that the mutation
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A Mutagen is a Mutagen, Not Necessarily a Carcinogen
1986A largely unspoken but underlying assumption that has been made by authors throughout these proceedings is that processes involved in antimutagenesis are related to anticarcinogenesis, a corollary of the somatic mutation theory of carcinogenesis.
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The Mutagenicity of Dinitrochlorobenzene
Archives of Dermatology, 1985A sample of dinitrochlorobenzene, determined by gas-liquid chromatography and mass spectrometry to be greater than 98% pure, was tested in the Salmonella typhimurium plate assay. The chemical evoked a marked mutagenic response at all concentrations tested (3 to 150 micrograms per plate).
Janette Gerguis +2 more
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