Results 211 to 220 of about 48,990 (266)
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Mutagenicity of sulphonylureas

Mutation Research/Genetic Toxicology, 1980
The 11 derivatives of beta-cytotropic sulphonylureas commonly used in the treatment of diabetes mellitus were tested in vivo in the highly sensitive sister-chromatid exchange test. Chlorpropamide and tolbutamide gave a positive reaction with a clear dose-response in Chinese hamsters and mice.
Ruth Münzner, H.W. Renner
openaire   +3 more sources

On the mutagenicity of nitrofurans

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
Donna Voutsinos, D.R. McCalla
openaire   +3 more sources

Structure-activity relationships and design of viral mutagens and application to lethal mutagenesis.

Journal of Medicinal Chemistry, 2013
While mutation is the driving force behind evolution, most mutations are detrimental; therefore, elevating the mutation rate of a virus should diminish fitness.
L. Bonnac, L. Mansky, S. Patterson
semanticscholar   +1 more source

Caffeine and other methylxanthines as interceptors of food-borne aromatic mutagens: inhibition of Trp-P-1 and Trp-P-2 mutagenic activity.

Chemical Research in Toxicology, 2013
Caffeine is one of the most important biologically active food components. In this article, we demonstrate that caffeine and other methylxanthines significantly reduce the mutagenic activity of two food-derived heterocyclic aromatic amines, Trp-P-1 and ...
A. Woziwodzka   +4 more
semanticscholar   +1 more source

Mutagenicity of Dichlorvos

Nature, 1972
THERE have been several conflicting reports on the genetic effects of Dichlorvos (2,2-dichlorovinyl dimethyl phosphate), which is the active ingredient of Shell's pesticide, ‘Vapona’.
J. Trevino, M. J. Ashwood-Smith, R. Ring
openaire   +3 more sources

Mutagenicity of proanthocyanidins

Food and Chemical Toxicology, 1987
Several procyanidins with different degrees of polymerization (dimers, a trimer and a polymer) and extracted from different natural sources were found to be non-mutagenic in the Salmonella mutagenesis assay system. A mutagenic impurity in procyanidin B-4 was isolated by means of reversed-phase high-performance liquid chromatography (HPLC) and ...
C.-L. Yu, B. Swaminathan
openaire   +3 more sources

Mutagenicity of acrylonitrile

Toxicology, 1978
Incubation of Salmonella typhimurium strains in an atmosphere of 0.2% gaseous acrylonitrile increased the numbers of his+ revertants/plate only in the presence of a fortified S9 liver fraction. The mutagenic effect was particularly pronounced with strains TA1530, TA1535 and TA1950 and much weaker with strains TA100, TA98 and TA1978.
F. Poncelet   +3 more
openaire   +2 more sources

Mutagenicity of radiations and chemical mutagens in Sorghum

Theoretical and Applied Genetics, 1970
A comparative study on the relative mutagenicity of radiations (X-and gamma rays) and chemical mutagens (EMS, MMS, dES and NEU) in inducing chlorophyll, viable and total mutations was made on three cultivated varieties (Co. 11, Co. 12 and Co. 18) of Eu-Sorghum. A critical comparison of the chlorophyll, viable and total mutations shows that the mutation
openaire   +3 more sources

A Mutagen is a Mutagen, Not Necessarily a Carcinogen

1986
A largely unspoken but underlying assumption that has been made by authors throughout these proceedings is that processes involved in antimutagenesis are related to anticarcinogenesis, a corollary of the somatic mutation theory of carcinogenesis.
openaire   +3 more sources

The Mutagenicity of Dinitrochlorobenzene

Archives of Dermatology, 1985
A sample of dinitrochlorobenzene, determined by gas-liquid chromatography and mass spectrometry to be greater than 98% pure, was tested in the Salmonella typhimurium plate assay. The chemical evoked a marked mutagenic response at all concentrations tested (3 to 150 micrograms per plate).
Janette Gerguis   +2 more
openaire   +3 more sources

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