Results 111 to 120 of about 2,692,923 (420)

A dysflagellar mutant of Leishmania (Viannia) braziliensis isolated from a cutaneous leishmaniasis patient

Parasites & Vectors, 2012
Background Parasites of the Leishmania genus alternate between the flagellated extracellular promastigote stage and intracellular amastigotes. Here we report the characterization of a Leishmania isolate, obtained from a cutaneous leishmaniasis patient ...
Zauli Rogéria C, Yokoyama-Yasunaka Jenicer KU, Miguel Danilo C, Moura Alexandre S, Pereira Ledice IA, da Silva Ildefonso A, Lemes Lucianna GN, Dorta Miriam L, de Oliveira Milton AP, Pitaluga André N, Ishikawa Edna AY, Rodrigues Juliany CF, Traub-Cseko Yara M, Bijovsky A, Ribeiro-Dias Fátima, Uliana Silvia RB   +15 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma [PDF]

, 2018
Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors.
Daylan, Ayse Ece Cali, Del Vecchio, Annachiara, Espinoza, Carlos, Fabo, Tania, Fearon, Eric R., Feng, Ying, Galbán, Stefanie, Halbrook, Christopher J., Karim, Saadia A., Kovalenko, Ilya, Kremer, Daniel M., Kumar-Sinha, Chandan, Lee, Ho-Joon, Ljungman, Mats, Lyssiotis, Costas A., Magnuson, Brian, Morton, Jennifer P., Pasca di Magliano, Marina, Schofield, Heather K., Yan, Wei, Zeller, Jörg   +20 more
core   +1 more source

Comprehensive mapping and modelling of the rice regulome landscape unveils the regulatory architecture underlying complex traits

Nature Communications
Unraveling the regulatory mechanisms that govern complex traits is pivotal for advancing crop improvement. Here we present a comprehensive regulome atlas for rice (Oryza sativa), charting the chromatin accessibility across 23 distinct tissues from three ...
Tao Zhu, Chunjiao Xia, Ranran Yu, Xinkai Zhou, Xingbing Xu, Lin Wang, Zhanxiang Zong, Junjiao Yang, Yinmeng Liu, Luchang Ming, Yuxin You, Dijun Chen, Weibo Xie   +12 more
doaj   +1 more source

Assessment of drought tolerance in Nagina 22 mutants of rice using Poly Ethylene Glycol (PEG)

Electronic Journal of Plant Breeding, 2020
A laboratory experiment was conducted to screen 500 EMS induced mutants of Nagina22 using low molecular osmotic PEG-6000. The analysis of variance showed that all ten characters showed significant variation at 1% probability level.
K. Manonmani, P. Jeyaprakash, S. Manonmani, M. Raveendran and P. Jeyakumar
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Selecting Fault Revealing Mutants [PDF]

arXiv, 2018
Mutant selection refers to the problem of choosing, among a large number of mutants, the (few) ones that should be used by the testers. In view of this, we investigate the problem of selecting the fault revealing mutants, i.e., the mutants that are most likely to be killable and lead to test cases that uncover unknown program faults.
arxiv  

Genetic, molecular and expression features of the Pervenets mutant leading to high oleic acid content of seed oil in sunflower

Oléagineux, Corps gras, Lipides, 2002
Pervenets is a sunflower population that displays seed oil with a high oleic acid content [HOAC]. Our aim is to reconcile all the data gathered on this mutant in a unique explanatory mechanism.
Lacombe Séverine, Leger Sandrine, Kaan François, Berville André, Sas Monsanto   +4 more
doaj   +1 more source

Generation and Characterization of a Foxtail Millet (Setaria italica) Mutant Library

Frontiers in Plant Science, 2019
Foxtail millet (Setaria italica) is attractive to plant scientists as a model plant because of several distinct characteristics, such as its short stature, rapid life cycle, sufficient seed production per plant, self-compatibility, true diploid nature ...
Jing Sun, Ngoc Sinh Luu, Zhenhua Chen, Bing Chen, Xuean Cui, Jinxia Wu, Zhiguo Zhang, Tiegang Lu   +7 more
doaj   +1 more source