Results 111 to 120 of about 2,828,087 (336)

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Nature Communications, 2017
TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed.
David S. Liu, C. Duong, S. Haupt, K. Montgomery, C. House, Walid J Azar, Helen B Pearson, O. Fisher, M. Read, Glen R Guerra, Y. Haupt, C. Cullinane, K. Wiman, L. Abrahmsén, W. Phillips, N. Clemons   +15 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Comparative Transcriptomic Analysis of Gossypium hirsutum Fiber Development in Mutant Materials (xin w 139) Provides New Insights into Cotton Fiber Development

Plants
Cotton is the most widely planted fiber crop in the world, and improving cotton fiber quality has long been a research hotspot. The development of cotton fibers is a complex process that includes four consecutive and overlapping stages, and although many
Chunping Li, Jieyin Zhao, Zhongshan Liu, Yanlong Yang, Chengxia Lai, Jun Ma, Alifu Aierxi   +6 more
doaj   +1 more source

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]

, 2015
Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T, Hall, David H, Nguyen, Ken CQ, Rose, Lesilee S, VanGompel, Michael JW   +4 more
core   +2 more sources

A novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway

, 2022
Zexiao Jia, Shuxu Yang, Mengyao Li, Zhaoying Lei, Xue Ding, Mingjie Fan, Dixian Wang, Dajiang Xie, Hui Zhou, Yue Qiu, Qianqian Zhuang, Dan Li, Wei Yang, Xuchen Qi, Xiaohui Cang, Jingwei Zhao, Wenqi Wang, Aifu Lin, Qingfeng Yan   +18 more
openalex   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Genetic, molecular and expression features of the Pervenets mutant leading to high oleic acid content of seed oil in sunflower

Oléagineux, Corps gras, Lipides, 2002
Pervenets is a sunflower population that displays seed oil with a high oleic acid content [HOAC]. Our aim is to reconcile all the data gathered on this mutant in a unique explanatory mechanism.
Lacombe Séverine, Leger Sandrine, Kaan François, Berville André, Sas Monsanto   +4 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Assessment of drought tolerance in Nagina 22 mutants of rice using Poly Ethylene Glycol (PEG)

Electronic Journal of Plant Breeding, 2020
A laboratory experiment was conducted to screen 500 EMS induced mutants of Nagina22 using low molecular osmotic PEG-6000. The analysis of variance showed that all ten characters showed significant variation at 1% probability level.
K. Manonmani, P. Jeyaprakash, S. Manonmani, M. Raveendran and P. Jeyakumar
doaj   +1 more source

The Role of CaMK-II in the Development of Leukemia/Lymphoma in Danio Rerio [PDF]

, 2017
Acute lymphocytic leukemia (ALL) is a blood disorder characterized by aberrant proliferation of immature lymphocytes. ALL is the most common cancer in children and can result from external influences, such as radiation, or internal influences, such as ...
Mohammadi, Daniel
core   +1 more source