Results 111 to 120 of about 2,692,923 (420)
Background Parasites of the Leishmania genus alternate between the flagellated extracellular promastigote stage and intracellular amastigotes. Here we report the characterization of a Leishmania isolate, obtained from a cutaneous leishmaniasis patient ...
Zauli Rogéria C+15 more
doaj +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma [PDF]
Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors.
Daylan, Ayse Ece Cali+20 more
core +1 more source
Unraveling the regulatory mechanisms that govern complex traits is pivotal for advancing crop improvement. Here we present a comprehensive regulome atlas for rice (Oryza sativa), charting the chromatin accessibility across 23 distinct tissues from three ...
Tao Zhu+12 more
doaj +1 more source
Assessment of drought tolerance in Nagina 22 mutants of rice using Poly Ethylene Glycol (PEG)
A laboratory experiment was conducted to screen 500 EMS induced mutants of Nagina22 using low molecular osmotic PEG-6000. The analysis of variance showed that all ten characters showed significant variation at 1% probability level.
K. Manonmani, P. Jeyaprakash, S. Manonmani, M. Raveendran and P. Jeyakumar
doaj +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
Selecting Fault Revealing Mutants [PDF]
Mutant selection refers to the problem of choosing, among a large number of mutants, the (few) ones that should be used by the testers. In view of this, we investigate the problem of selecting the fault revealing mutants, i.e., the mutants that are most likely to be killable and lead to test cases that uncover unknown program faults.
arxiv
Pervenets is a sunflower population that displays seed oil with a high oleic acid content [HOAC]. Our aim is to reconcile all the data gathered on this mutant in a unique explanatory mechanism.
Lacombe Séverine+4 more
doaj +1 more source
Generation and Characterization of a Foxtail Millet (Setaria italica) Mutant Library
Foxtail millet (Setaria italica) is attractive to plant scientists as a model plant because of several distinct characteristics, such as its short stature, rapid life cycle, sufficient seed production per plant, self-compatibility, true diploid nature ...
Jing Sun+7 more
doaj +1 more source