Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease [PDF]
, 2018 Zhen Zheng +8 more
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Constraints of FL Motif on the Targeting and Function of Sodium-Bicarbonate Cotransporter 1 [PDF]
, 2008 A C-terminal dihydrophobic FL motif plays a vital role in the basolateral targeting of sodium bicarbonate cotransporter 1. To further characterize the role of dihydrophobic FL motif, 1). the FL motif in wild type (PFLS) was reversed to LF (PLFS), 2). the
Ali Shawki +7 more
core +1 more source
Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy [PDF]
, 2016 Gun West +14 more
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
T790M mutant copy number quantified via ddPCR predicts outcome after osimertinib treatment in lung cancer [PDF]
, 2018 Jacky Yu-Chung Li, Jcm Ho, Kam-Hung Wong
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YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Structural aspects of ectomycorrhiza ofPinus pinaster(Ait.) Sol. formed by an IAA‐overproducer mutant ofHebeloma cylindrosporumRomagnési [PDF]
, 1994 L. Gea +3 more
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Fermentation performance of Bacillus subtilis wild type and alsS- mutant using different carbon sources [PDF]
, 2022 Ofelia E. Carreón-Rodríguez +2 more
openalex +1 more source