Results 231 to 240 of about 1,574,250 (305)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

DNA polymerase ε-mutant endometrial carcinosarcoma: A case report and literature review. [PDF]

Exp Ther Med
Zhang Y, Huang B, Ge H.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

<i>Staphylococcus aureus</i> wall teichoic acid structure dictates virulence potential and resistance to host defenses. [PDF]

Sci Adv
Enroth TJ, Lee E, Eisenmesser EZ, Horswill AR.   +3 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Fluorodeoxyglucose Metabolic Phenotypes Across Molecular Subgroups of Primary Colorectal Cancer: A Retrospective Three-Group Analysis. [PDF]

J Clin Med
Morita R, Norikane T, Yamamoto Y, Manabe Y, Murao M, Obata T, Mitamura K, Okuyama H, Nishiyama Y.   +8 more
europepmc   +1 more source

Regulation of central carbon metabolism and storage polymers by PTS^Ntr in <i>Rhizobium leguminosarum</i>. [PDF]

Appl Environ Microbiol
Tjahjono O, Wang J, Turner E, Prell J, Huang WE, Poole PS, Sánchez-Cañizares C.   +6 more
europepmc   +1 more source

<i>KAT6A</i>-Mutant iPSC-Derived Cortical Neurons Display Precocious Maturation, Dysregulated Electrophysiology, and Altered Morphology. [PDF]

Int J Biol Sci
Wiesel-Motiuk N, Choudhary A, Hussein Y, Tripathi U, Rike WA, Shemen A, Nayak R, Chakraborty S, Sharma O, Rabinski T, Stark M, Weiss K, Vatine GD, Stern S, Assaraf YG.   +14 more
europepmc   +1 more source