Results 211 to 220 of about 1,574,250 (305)

The Impact of SF3B1 Mutations on the Tumor Microenvironment and Response to Immunotherapy. [PDF]

Cancer Med
Cho KJ, Lim B.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Structural insights into Mitoguardin-1-mediated mitochondrial contact surfaces in fusion and lipid binding. [PDF]

Cell Discov
Yang K, Deng J, Yu F, Wang L, Yuan X, Ruan K, Yao X, Shi Y, Zhang L.   +8 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Time-ordered co-expression network analysis reveals <i>b</i>-locus-mediated transcriptional cascades underlying sugarcane resistance to smut fungus (<i>Sporisorium scitamineum</i>). [PDF]

Front Plant Sci
Song XP, Zhang XQ, Lu BQ, Huang DM, Liang YJ, Zhang BQ, Deng YC, Li DM, Li YR, Liang Q, Verma KK, Yan MX.   +11 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A PhoP-regulated type II secretion system drives bacterial competition in <i>Serratia marcescens</i>. [PDF]

Microbiol Spectr
Sartori MS, Arango Gil BS, García Véscovi E, Mariscotti JF.   +3 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials. [PDF]

J Gastrointest Cancer
Kazmi SK, Rehman MA, Tariq H, Kabir A, Ahmed J, Yee NSS.   +5 more
europepmc   +1 more source