Results 201 to 210 of about 1,109,048 (266)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Current and emerging therapies in IDH-mutant glioma. [PDF]

Neurotherapeutics
Nakhate V, Youssef G, Wen PY.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

NADPH Dehydrogenase Gene Regulates Energy Distribution and Fatty Acid Metabolism During Fruiting Body Formation in the Filamentous Fungus Podospora anserina. [PDF]

Microb Biotechnol
Qiu Y, Nwankwegu AS, Sun Y, Li Y, Chen W, Liu G, Xie N.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Limited Immune-Mediated Efficacy of Anti-PD-L1/VEGF in EGFR-TKI-Naïve <i>Egfr</i>-Mutant Lung Cancer with Non-Inflamed Tumor Microenvironment. [PDF]

Curr Oncol
Hirabae A, Kuribayashi T, Tomida S, Okawa S, Nakasuka T, Nishii K, Nishimura J, Makimoto G, Ninomiya K, Higo H, Rai K, Ichihara E, Hotta K, Sugimoto M, Togashi Y, Maeda Y, Kiura K, Ohashi K.   +17 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease. [PDF]

Transl Neurodegener
Sheshadri P, Costa-Besada MA, Fisher A, Kiraly S, Singh K, Kourouzidou I, Blacker TS, Zeng J, Shirihai OS, Grinstaff MW, Duchen MR.   +10 more
europepmc   +1 more source

<i>OsBADH1-OsBADH2</i> Double Mutants Increase 2-Acetyl-1-Pyrroline Accumulation and Alter GABA-Associated Abiotic Stress Responses in Rice. [PDF]

Genes (Basel)
Jung YJ, Kim JY, Kang KK.
europepmc   +1 more source

Slirp2 modulates oogenesis via regulating mitochondrial protein translation. [PDF]

J Mol Cell Biol
Cao J, Zhang J, Wu Z, Luan W, Zhou Y, Huang H, Li L, Hu W.   +7 more
europepmc   +1 more source